Exfoliation syndrome and systemic cardiovascular diseases

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Exfoliation syndrome (XFS) is a systemic condition. Intraocular alterations represent only a part of the exfoliationrelated clinical signs. Exfoliation material has been identified in the visceral organs, skin, and vessel walls. This triggered several studies that investigated association between XFS and cardiovascular diseases. In many populations, significant associations between XFS and various systemic vascular diseases including elevated plasma homocysteine level, myocardial dysfunction, stroke, aortic aneurysm, and white matter lesions were found. Some of these XFS-associated vascular diseases are caused by elastosis of the vessel wall, which may be directly related to general extracellular dysfunction in XFS. Another part of the pathologic vascular alterations (reduced cutaneous capillary flow reactions, impaired baroreflex sensitivity, parasympathetic cardiovascular neuropathy, and pathologic heart rate variability indices), however, suggests that vascular dysregulation beyond the age-related normal decline may also play a role both in the development and worsening of the systemic cardiovascular diseases in XFS. The exact mechanism of the development of systemic vascular dysregulation associated with XFS is currently unknown.

Original languageEnglish
Pages (from-to)S9-S11
JournalJournal of Glaucoma
Volume23
Issue number8
DOIs
Publication statusPublished - Dec 10 2014

Fingerprint

Exfoliation Syndrome
Blood Vessels
Cardiovascular Diseases
Vascular Diseases
Skin
Baroreflex
Aortic Aneurysm
Homocysteine
Heart Rate
Stroke
Population

Keywords

  • Baroreflex sensitivity
  • Cardiovascular diseases
  • Exfoliation syndrome
  • Heart rate variability
  • Vascular dysregulation

ASJC Scopus subject areas

  • Ophthalmology
  • Medicine(all)

Cite this

Exfoliation syndrome and systemic cardiovascular diseases. / Holló, G.

In: Journal of Glaucoma, Vol. 23, No. 8, 10.12.2014, p. S9-S11.

Research output: Contribution to journalArticle

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