Excitotoxic mechanisms in non-motor dysfunctions and levodopa- induced dyskinesia in Parkinson's disease: The role of the interaction between the dopaminergic and the kynurenine system

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3 Citations (Scopus)

Abstract

Parkinson's disease is a common progressive neurodegenerative disorder presenting with characteristic motor symptoms. Non-motor dysfunctions and therapyrelated complications frequently develop, but are often underdiagnosed and undertreated. Levodopa- induced dyskinesia and impulse control disorders are suggested to share pathophysiological processes and m a y be related to alterations of the glutamatergic neurotransmission. Anti- glutamatergic interventions are therefore worth considering: several lines of evidence already indicate their beneficial effect. The kynurenine pathway offers the endogenous glutamate receptor antagonist kynurenic acid, which may act as a promising candidate for future drug development with the aim of assessment of the motor symptoms and therapy-related complications of Parkinson's disease.

Original languageEnglish
Pages (from-to)874-883
Number of pages10
JournalCurrent medicinal chemistry
Volume23
Issue number9
DOIs
Publication statusPublished - Mar 1 2016

Keywords

  • Excitotoxicity
  • Glutamate
  • Kynurenic acid
  • Levodopa-induced dyskinesia
  • NMDA receptor
  • Neuroprotection
  • Parkinson's disease

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Drug Discovery
  • Organic Chemistry

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