Excitatory effect of GABAergic axo-axonic cells in cortical microcircuits

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Abstract

Axons in the cerebral cortex receive synaptic input at the axon initial segment almost exclusively from γ-aminobutyric acid-releasing (GABAergic) axo-axonic cells (AACs). The axon has the lowest threshold for action potential generation in neurons; thus, AACs are considered to be strategically placed inhibitory neurons controlling neuronal output. However, we found that AACs can depolarize pyramidal cells and can initiate stereotyped series of synaptic events in rat and human cortical networks because of a depolarized reversal potential for axonal relative to perisomatic GABAergic inputs. Excitation and signal propagation initiated by AACs is supported by the absence of the potassium chloride cotransporter 2 in the axon.

Original languageEnglish
Pages (from-to)233-235
Number of pages3
JournalScience
Volume311
Issue number5758
DOIs
Publication statusPublished - Jan 13 2006

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Axons
Aminobutyrates
Neurons
Pyramidal Cells
Cerebral Cortex
Action Potentials
potassium-chloride symporters
Axon Initial Segment

ASJC Scopus subject areas

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Excitatory effect of GABAergic axo-axonic cells in cortical microcircuits. / Szabadics, J.; Varga, C.; Molnár, G.; Oláh, Szabolcs; Barzó, P.; Tamás, G.

In: Science, Vol. 311, No. 5758, 13.01.2006, p. 233-235.

Research output: Contribution to journalArticle

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