Excimer laser-produced biodegradable photopolymer scaffolds do not induce immune rejection in vivo

Balázs Farkas, Adam Zsedenyi, Edina Gyukity-Sebestyen, Ilaria Romano, K. Nagy, Alberto Diaspro, Fernando Brandi, Krisztina Buzas, Szabolcs Beke

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Following our previous works of in-vitro tests, the biocompatibility of photopolymer scaffolds was tested against immune responses in vivo. Neither relevant immune reactions nor the rejection of implanted scaffolds was detected, being an essential step for in vivo implantation of excimer laser-prepared scaffolds. The scaffolds were fabricated by UV excimer laser photocuring at 308 nm. Af-ter two weeks of transplantation neither inflammatory response nor reactive immune activation was detected based on the chemokine and cytokine profile. As a sign of biodegradability of the scaffolds, we detected macrophage infiltration and phagocytosis of the biopolymer at the site of implantation. Our results suggest that poly(propylene fumarate) (PPF): diethyl fumarate (DEF) (7: 3 w/w) scaf-folds have appropriate properties for in vivo applications.

Original languageEnglish
Pages (from-to)11-14
Number of pages4
JournalJournal of Laser Micro Nanoengineering
Volume10
Issue number1
DOIs
Publication statusPublished - 2015

Fingerprint

Photopolymers
photopolymers
Excimer lasers
Scaffolds (biology)
Scaffolds
rejection
excimer lasers
implantation
biodegradability
transplantation
macrophages
biopolymers
biocompatibility
infiltration
ultraviolet lasers
polypropylene
Antigen-antibody reactions
Macrophages
Biodegradability
Biopolymers

Keywords

  • Biocompatibility
  • Biodegradation
  • Excimer lasers
  • In vivo experi-ments
  • Scaffold fabrication

ASJC Scopus subject areas

  • Industrial and Manufacturing Engineering
  • Instrumentation
  • Electrical and Electronic Engineering

Cite this

Excimer laser-produced biodegradable photopolymer scaffolds do not induce immune rejection in vivo. / Farkas, Balázs; Zsedenyi, Adam; Gyukity-Sebestyen, Edina; Romano, Ilaria; Nagy, K.; Diaspro, Alberto; Brandi, Fernando; Buzas, Krisztina; Beke, Szabolcs.

In: Journal of Laser Micro Nanoengineering, Vol. 10, No. 1, 2015, p. 11-14.

Research output: Contribution to journalArticle

Farkas, B, Zsedenyi, A, Gyukity-Sebestyen, E, Romano, I, Nagy, K, Diaspro, A, Brandi, F, Buzas, K & Beke, S 2015, 'Excimer laser-produced biodegradable photopolymer scaffolds do not induce immune rejection in vivo', Journal of Laser Micro Nanoengineering, vol. 10, no. 1, pp. 11-14. https://doi.org/10.2961/jlmn.2015.01.0002
Farkas, Balázs ; Zsedenyi, Adam ; Gyukity-Sebestyen, Edina ; Romano, Ilaria ; Nagy, K. ; Diaspro, Alberto ; Brandi, Fernando ; Buzas, Krisztina ; Beke, Szabolcs. / Excimer laser-produced biodegradable photopolymer scaffolds do not induce immune rejection in vivo. In: Journal of Laser Micro Nanoengineering. 2015 ; Vol. 10, No. 1. pp. 11-14.
@article{13355f88bfff44e3ba4049f1660254ae,
title = "Excimer laser-produced biodegradable photopolymer scaffolds do not induce immune rejection in vivo",
abstract = "Following our previous works of in-vitro tests, the biocompatibility of photopolymer scaffolds was tested against immune responses in vivo. Neither relevant immune reactions nor the rejection of implanted scaffolds was detected, being an essential step for in vivo implantation of excimer laser-prepared scaffolds. The scaffolds were fabricated by UV excimer laser photocuring at 308 nm. Af-ter two weeks of transplantation neither inflammatory response nor reactive immune activation was detected based on the chemokine and cytokine profile. As a sign of biodegradability of the scaffolds, we detected macrophage infiltration and phagocytosis of the biopolymer at the site of implantation. Our results suggest that poly(propylene fumarate) (PPF): diethyl fumarate (DEF) (7: 3 w/w) scaf-folds have appropriate properties for in vivo applications.",
keywords = "Biocompatibility, Biodegradation, Excimer lasers, In vivo experi-ments, Scaffold fabrication",
author = "Bal{\'a}zs Farkas and Adam Zsedenyi and Edina Gyukity-Sebestyen and Ilaria Romano and K. Nagy and Alberto Diaspro and Fernando Brandi and Krisztina Buzas and Szabolcs Beke",
year = "2015",
doi = "10.2961/jlmn.2015.01.0002",
language = "English",
volume = "10",
pages = "11--14",
journal = "Journal of Laser Micro Nanoengineering",
issn = "1880-0688",
publisher = "Japan Laser Processing",
number = "1",

}

TY - JOUR

T1 - Excimer laser-produced biodegradable photopolymer scaffolds do not induce immune rejection in vivo

AU - Farkas, Balázs

AU - Zsedenyi, Adam

AU - Gyukity-Sebestyen, Edina

AU - Romano, Ilaria

AU - Nagy, K.

AU - Diaspro, Alberto

AU - Brandi, Fernando

AU - Buzas, Krisztina

AU - Beke, Szabolcs

PY - 2015

Y1 - 2015

N2 - Following our previous works of in-vitro tests, the biocompatibility of photopolymer scaffolds was tested against immune responses in vivo. Neither relevant immune reactions nor the rejection of implanted scaffolds was detected, being an essential step for in vivo implantation of excimer laser-prepared scaffolds. The scaffolds were fabricated by UV excimer laser photocuring at 308 nm. Af-ter two weeks of transplantation neither inflammatory response nor reactive immune activation was detected based on the chemokine and cytokine profile. As a sign of biodegradability of the scaffolds, we detected macrophage infiltration and phagocytosis of the biopolymer at the site of implantation. Our results suggest that poly(propylene fumarate) (PPF): diethyl fumarate (DEF) (7: 3 w/w) scaf-folds have appropriate properties for in vivo applications.

AB - Following our previous works of in-vitro tests, the biocompatibility of photopolymer scaffolds was tested against immune responses in vivo. Neither relevant immune reactions nor the rejection of implanted scaffolds was detected, being an essential step for in vivo implantation of excimer laser-prepared scaffolds. The scaffolds were fabricated by UV excimer laser photocuring at 308 nm. Af-ter two weeks of transplantation neither inflammatory response nor reactive immune activation was detected based on the chemokine and cytokine profile. As a sign of biodegradability of the scaffolds, we detected macrophage infiltration and phagocytosis of the biopolymer at the site of implantation. Our results suggest that poly(propylene fumarate) (PPF): diethyl fumarate (DEF) (7: 3 w/w) scaf-folds have appropriate properties for in vivo applications.

KW - Biocompatibility

KW - Biodegradation

KW - Excimer lasers

KW - In vivo experi-ments

KW - Scaffold fabrication

UR - http://www.scopus.com/inward/record.url?scp=84923087123&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923087123&partnerID=8YFLogxK

U2 - 10.2961/jlmn.2015.01.0002

DO - 10.2961/jlmn.2015.01.0002

M3 - Article

AN - SCOPUS:84923087123

VL - 10

SP - 11

EP - 14

JO - Journal of Laser Micro Nanoengineering

JF - Journal of Laser Micro Nanoengineering

SN - 1880-0688

IS - 1

ER -