Szemelvények a Semmelweis Egyetem, az Országos Onkológiai Intézet és az Országos Korányi Tbc és Pulmonológiai Intézet együttmüködésén alapuló tüdörák-kutatási programból

Translated title of the contribution: Excerpts from the collaborative lung cancer research program of Semmelweis University, the National Institute of Oncology and Korányi Institute of TB and Pulmonology (2010-2015)

Hegedüs Balázs, Moldvay Judit, Berta Judit, Lohinai Zoltán, Rózsás Anita, Cserepes T. Mihály, Fábián Katalin, G. Ostoros, Tóvári József, Rényi Vámos Ferenc, J. Tímár, B. Döme

Research output: Contribution to journalArticle

Abstract

Lung cancer places a significant socio-economic burden on the Hungarian population. This overview summarizes the findings of collaborative translational lung cancer research efforts of three Hungarian flagship academic institutions, the Semmelweis University, the National Institute of Oncology and the National Koranyi Institute of TB and Pulmonology. With regards to the molecular factors regulating tumor angiogenesis, we identified the prognostic significance of apelin and erythropoietin receptor (EPOR) expression in non-small cell lung cancer (NSCLC). Furthermore, the impact of KRAS mutation subtypes and ERCC1 (excision repair cross-complementation group 1) expression on the response to platinum-based chemotherapy have been studied. We also described the epidemiology and predictive power of rare EGFR (epidermal growth factor receptor) mutations in a large Hungarian patient cohort. Lastly, the expression of molecular factors associated with NSCLC progression was studied specifically in brain metastatic matched cases series. These preclinical and clinical studies provide clinically relevant information that hopefully will contribute to the improvement of lung cancer patient care.

Original languageHungarian
Pages (from-to)282-285
Number of pages4
JournalMagyar Onkologia
Volume59
Issue number4
Publication statusPublished - Jan 1 2015

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Pulmonary Medicine
Lung Neoplasms
Non-Small Cell Lung Carcinoma
Research
Erythropoietin Receptors
Mutation
Platinum
Epidermal Growth Factor Receptor
DNA Repair
Patient Care
Epidemiology
Economics
Drug Therapy
Brain
Population
Neoplasms

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Szemelvények a Semmelweis Egyetem, az Országos Onkológiai Intézet és az Országos Korányi Tbc és Pulmonológiai Intézet együttmüködésén alapuló tüdörák-kutatási programból. / Balázs, Hegedüs; Judit, Moldvay; Judit, Berta; Zoltán, Lohinai; Anita, Rózsás; Mihály, Cserepes T.; Katalin, Fábián; Ostoros, G.; József, Tóvári; Ferenc, Rényi Vámos; Tímár, J.; Döme, B.

In: Magyar Onkologia, Vol. 59, No. 4, 01.01.2015, p. 282-285.

Research output: Contribution to journalArticle

Balázs, Hegedüs ; Judit, Moldvay ; Judit, Berta ; Zoltán, Lohinai ; Anita, Rózsás ; Mihály, Cserepes T. ; Katalin, Fábián ; Ostoros, G. ; József, Tóvári ; Ferenc, Rényi Vámos ; Tímár, J. ; Döme, B. / Szemelvények a Semmelweis Egyetem, az Országos Onkológiai Intézet és az Országos Korányi Tbc és Pulmonológiai Intézet együttmüködésén alapuló tüdörák-kutatási programból. In: Magyar Onkologia. 2015 ; Vol. 59, No. 4. pp. 282-285.
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