Examination of the polymorphism of piroxicam in connection with the preparation of a new 'soft-patch' type pharmaceutical dosage form

G. Csóka, E. Balogh, S. Marton, E. Farkas, I. Rácz

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

The influence of different solvents (propylene glycol, glycerol, ethanol), as well as different technological procedures (melting, rapid and slow cooling), on the formation of polymorphous piroxicam modifications was examined in the course of the elaboration of a 'soft-patch' type of semisolid pharmaceutical dosage form. The thermodynamical behavior, some physicochemical properties (such as melting point, dissolution rate), and infrared (IR) spectrum of the formed (needle and cubic) crystal modifications were studied, and the possibilities of their formation and their avoidance were examined.

Original languageEnglish
Pages (from-to)813-816
Number of pages4
JournalDrug Development and Industrial Pharmacy
Volume25
Issue number6
DOIs
Publication statusPublished - 1999

Fingerprint

Piroxicam
Propylene Glycol
Dosage Forms
Polymorphism
Needles
Glycerol
Freezing
Melting point
Dissolution
Melting
Ethanol
Cooling
Infrared radiation
Crystals
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Drug Discovery
  • Organic Chemistry
  • Pharmacology
  • Molecular Medicine

Cite this

Examination of the polymorphism of piroxicam in connection with the preparation of a new 'soft-patch' type pharmaceutical dosage form. / Csóka, G.; Balogh, E.; Marton, S.; Farkas, E.; Rácz, I.

In: Drug Development and Industrial Pharmacy, Vol. 25, No. 6, 1999, p. 813-816.

Research output: Contribution to journalArticle

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