Examination of the interaction of different lighting conditions and chronic mild stress in animal model

A. Muller, N. Gal, J. Betlehem, N. Fuller, P. Acs, G. Kovács, K. Fusz, R. Józsa, A. Olah

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

We examined the effects of different shift work schedules and chronic mild stress (CMS) on mood using animal model. The most common international shift work schedules in nursing were applied by three groups of Wistar-rats and a control group with normal light-dark cycle. One subgroup from each group was subjected to CMS. Levels of anxiety and emotional life were evaluated in light-dark box. Differences between the groups according to independent and dependent variables were examined with one- And two-way analysis of variance, with a significance level defined at p <0.05. Interaction of lighting regimen and CMS was proved to be significant according to time spent in the light compartment and the average number of changes between the light and dark compartments. Results of our examination confirm that the changes of lighting conditions evocate anxiety more prominently than CMS. No significant differences were found between the results of the low rotating group and the control group, supposing that this schedule is the least harmful to health. Our results on the association between the use of lighting regimens and the level of CMS provide evidence that the fast rotating shift work schedule puts the heaviest load on the organism of animals.

Original languageEnglish
Pages (from-to)301-310
Number of pages10
JournalActa Physiologica Hungarica
Volume102
Issue number3
DOIs
Publication statusPublished - Sep 1 2015

Fingerprint

Lighting
Appointments and Schedules
Animal Models
Light
Anxiety
Control Groups
Photoperiod
Wistar Rats
Analysis of Variance
Nursing
Health

Keywords

  • Animal models
  • Anxiety
  • Chronic mild stress
  • Light-dark box test
  • Modelling of shift work
  • Shift work

ASJC Scopus subject areas

  • Physiology (medical)

Cite this

Examination of the interaction of different lighting conditions and chronic mild stress in animal model. / Muller, A.; Gal, N.; Betlehem, J.; Fuller, N.; Acs, P.; Kovács, G.; Fusz, K.; Józsa, R.; Olah, A.

In: Acta Physiologica Hungarica, Vol. 102, No. 3, 01.09.2015, p. 301-310.

Research output: Contribution to journalArticle

Muller, A. ; Gal, N. ; Betlehem, J. ; Fuller, N. ; Acs, P. ; Kovács, G. ; Fusz, K. ; Józsa, R. ; Olah, A. / Examination of the interaction of different lighting conditions and chronic mild stress in animal model. In: Acta Physiologica Hungarica. 2015 ; Vol. 102, No. 3. pp. 301-310.
@article{7b408ab86ad14de69ac223657ed4b91b,
title = "Examination of the interaction of different lighting conditions and chronic mild stress in animal model",
abstract = "We examined the effects of different shift work schedules and chronic mild stress (CMS) on mood using animal model. The most common international shift work schedules in nursing were applied by three groups of Wistar-rats and a control group with normal light-dark cycle. One subgroup from each group was subjected to CMS. Levels of anxiety and emotional life were evaluated in light-dark box. Differences between the groups according to independent and dependent variables were examined with one- And two-way analysis of variance, with a significance level defined at p <0.05. Interaction of lighting regimen and CMS was proved to be significant according to time spent in the light compartment and the average number of changes between the light and dark compartments. Results of our examination confirm that the changes of lighting conditions evocate anxiety more prominently than CMS. No significant differences were found between the results of the low rotating group and the control group, supposing that this schedule is the least harmful to health. Our results on the association between the use of lighting regimens and the level of CMS provide evidence that the fast rotating shift work schedule puts the heaviest load on the organism of animals.",
keywords = "Animal models, Anxiety, Chronic mild stress, Light-dark box test, Modelling of shift work, Shift work",
author = "A. Muller and N. Gal and J. Betlehem and N. Fuller and P. Acs and G. Kov{\'a}cs and K. Fusz and R. J{\'o}zsa and A. Olah",
year = "2015",
month = "9",
day = "1",
doi = "10.1556/036.102.2015.3.8",
language = "English",
volume = "102",
pages = "301--310",
journal = "Physiology International",
issn = "2498-602X",
publisher = "Akademiai Kiado",
number = "3",

}

TY - JOUR

T1 - Examination of the interaction of different lighting conditions and chronic mild stress in animal model

AU - Muller, A.

AU - Gal, N.

AU - Betlehem, J.

AU - Fuller, N.

AU - Acs, P.

AU - Kovács, G.

AU - Fusz, K.

AU - Józsa, R.

AU - Olah, A.

PY - 2015/9/1

Y1 - 2015/9/1

N2 - We examined the effects of different shift work schedules and chronic mild stress (CMS) on mood using animal model. The most common international shift work schedules in nursing were applied by three groups of Wistar-rats and a control group with normal light-dark cycle. One subgroup from each group was subjected to CMS. Levels of anxiety and emotional life were evaluated in light-dark box. Differences between the groups according to independent and dependent variables were examined with one- And two-way analysis of variance, with a significance level defined at p <0.05. Interaction of lighting regimen and CMS was proved to be significant according to time spent in the light compartment and the average number of changes between the light and dark compartments. Results of our examination confirm that the changes of lighting conditions evocate anxiety more prominently than CMS. No significant differences were found between the results of the low rotating group and the control group, supposing that this schedule is the least harmful to health. Our results on the association between the use of lighting regimens and the level of CMS provide evidence that the fast rotating shift work schedule puts the heaviest load on the organism of animals.

AB - We examined the effects of different shift work schedules and chronic mild stress (CMS) on mood using animal model. The most common international shift work schedules in nursing were applied by three groups of Wistar-rats and a control group with normal light-dark cycle. One subgroup from each group was subjected to CMS. Levels of anxiety and emotional life were evaluated in light-dark box. Differences between the groups according to independent and dependent variables were examined with one- And two-way analysis of variance, with a significance level defined at p <0.05. Interaction of lighting regimen and CMS was proved to be significant according to time spent in the light compartment and the average number of changes between the light and dark compartments. Results of our examination confirm that the changes of lighting conditions evocate anxiety more prominently than CMS. No significant differences were found between the results of the low rotating group and the control group, supposing that this schedule is the least harmful to health. Our results on the association between the use of lighting regimens and the level of CMS provide evidence that the fast rotating shift work schedule puts the heaviest load on the organism of animals.

KW - Animal models

KW - Anxiety

KW - Chronic mild stress

KW - Light-dark box test

KW - Modelling of shift work

KW - Shift work

UR - http://www.scopus.com/inward/record.url?scp=84946058384&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84946058384&partnerID=8YFLogxK

U2 - 10.1556/036.102.2015.3.8

DO - 10.1556/036.102.2015.3.8

M3 - Article

C2 - 26551746

AN - SCOPUS:84946058384

VL - 102

SP - 301

EP - 310

JO - Physiology International

JF - Physiology International

SN - 2498-602X

IS - 3

ER -