Examination of the interaction of Decis and Dithane in rats

J. Szépvölgyi, K. Nagy, M. Bedó, A. Regöly-Mérei, M. Szerletics, K. Soós, M. Antal

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Acute (LD50) and short-term (14 days) toxicological examinations were performed in animal experiments on the interaction of a synthetic pyrethroid Decis 2,5 EC (25 g deltamethrin/l) and of ethylene-bisdithiocarbamate/Dithane M-45 (80% mancozeb), using a 1:5 deltamethrin/mancozeb mixture. LD50 value of the mixture was similar to that of the more toxic Decis. In the short-term examination, some pathologically high AST and ALT values were observed in the treated groups and the deltamethrin content of fatty tissue samples increased parallel with the increase of Decis consumption. The chymotrypsin and lipase activities in the small intestinal mucosa and γ-GT and LAP activities in the content of the bowels were reduced in several treated groups. The administration of Dithane in a dose in accordance with 20% of the LD50 value (3125 mg/kg b.m.) proved to be moer toxic than expected and caused the death of the animals.

Original languageEnglish
Pages (from-to)107-111
Number of pages5
JournalToxicology
Volume53
Issue number1
DOIs
Publication statusPublished - Dec 16 1988

Fingerprint

Rats
Lethal Dose 50
Poisons
Animals
Pyrethrins
Chymotrypsin
Intestinal Mucosa
Lipase
Toxicology
decamethrin
Adipose Tissue
Tissue
Experiments
mancozeb

Keywords

  • Deltamethrin
  • Deltamethrin content of the fatty tissue
  • Ethylene-bisdithiocarbamate
  • Pyrethroid
  • Serum- and gut-enzymes

ASJC Scopus subject areas

  • Toxicology

Cite this

Szépvölgyi, J., Nagy, K., Bedó, M., Regöly-Mérei, A., Szerletics, M., Soós, K., & Antal, M. (1988). Examination of the interaction of Decis and Dithane in rats. Toxicology, 53(1), 107-111. https://doi.org/10.1016/0300-483X(88)90240-5

Examination of the interaction of Decis and Dithane in rats. / Szépvölgyi, J.; Nagy, K.; Bedó, M.; Regöly-Mérei, A.; Szerletics, M.; Soós, K.; Antal, M.

In: Toxicology, Vol. 53, No. 1, 16.12.1988, p. 107-111.

Research output: Contribution to journalArticle

Szépvölgyi, J, Nagy, K, Bedó, M, Regöly-Mérei, A, Szerletics, M, Soós, K & Antal, M 1988, 'Examination of the interaction of Decis and Dithane in rats', Toxicology, vol. 53, no. 1, pp. 107-111. https://doi.org/10.1016/0300-483X(88)90240-5
Szépvölgyi J, Nagy K, Bedó M, Regöly-Mérei A, Szerletics M, Soós K et al. Examination of the interaction of Decis and Dithane in rats. Toxicology. 1988 Dec 16;53(1):107-111. https://doi.org/10.1016/0300-483X(88)90240-5
Szépvölgyi, J. ; Nagy, K. ; Bedó, M. ; Regöly-Mérei, A. ; Szerletics, M. ; Soós, K. ; Antal, M. / Examination of the interaction of Decis and Dithane in rats. In: Toxicology. 1988 ; Vol. 53, No. 1. pp. 107-111.
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