The authors examined the effect of single im. administration of vitamin D3 (100 000 IU cholecalciferol) on Ca and P metabolism in the rabbit. During the 7-day-examination period the excretion of the two macro-elements through urine and faeces was followed with 32P and 45Ca isotopes. The amount of 32P and 45Ca excretion through faeces had not changed as a result of vitamin treatment. Following the administration of vitamin D3 the renal excretion of the two mineral substances were different. In case of phosphorus following the vitamin treatment the animals excreted more radiophosphorus each day of examination than those belonging to the control group. On the other hand vitamin D3 decreased significantly the renal excretion of radiocalcium. The single large dose of vitamin increased slightly the incorporation of 45Ca into the bones. On the basis of these results it seems that in rabbits vitamin D3 increases the tubular reabsorption of Ca2+ but it does not increase that of inorganic phosphate. The authors proved with autoradiograms of bones taken two hours following iv. administration of 32P and 45Ca that in case of both of the elements the incorporation of isotopes from intravascular space into skeletal system is a very rapid process.
|Translated title of the contribution||Examination of the effect of vitamin D3 on Ca and P metabolism in the rabbit with isotope method|
|Number of pages||5|
|Journal||Magyar Allatorvosok Lapja|
|Publication status||Published - Dec 1 2000|
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