Examination of the dissolution of albendazole from anthelmintic veterinary suspensions

E. J. Biró, I. Rácz, T. Bán

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

When developing a new pharmaceutical dosage form, the in vitro examination of the dissolution properties of active ingredients may yield valuable information about the pharmaceutical properties and the duration of its therapeutic action. A drug administered in any other than intravenous way can exert the expected action only if the active substance is set free from the given pharmaceutical dosage form at the appropriate place and in the 'appropriate biological medium of the organism, and its absorption corresponds, in space and time, to the physiological requirements [1]. When specialities of the same pharmaceutical dosage form and containing the same active ingredient are compared with each other, an expert can obtain precious information already in laboratory scale [2]. The pur pose of the present study was to examine the liberation of the active substance from albendazole containing suspensions in artifical rumen and abomasal fluids of cattle.

Original languageEnglish
Pages (from-to)77-90
Number of pages14
JournalScientia Pharmaceutica
Volume66
Issue number1
Publication statusPublished - Mar 30 1998

Keywords

  • Albendazole
  • Drug liberation
  • Gastrointestinal tract modelling
  • Gastrointestinal tract of ruminants
  • Suspension viscosity

ASJC Scopus subject areas

  • Pharmaceutical Science

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