Examination of stomach wall Mg2+-Na+-K+-dependent ATPase, ATP, and ADP in pylorus-ligated rats

G. Mózsik, F. Vizi

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Stomach wall Mg2+-Na+-K+-dependent ATPase, ATP, and ADP were studied in rats, at 4, 7, 17, and 24 hr after pylorus ligation, in order to relate H+ secretion and ulcer development. It was observed, in both parts of forestomach and corpus + antrum, that the stomach wall Mg2+-Na+-K+-dependent ATPase significantly increased at 4 and 7 hr, while it significantly decreased at 24 hr, after pylorus ligation. Contrary to this, stomach-wall ATP decreased at 4 hr, relatively increased at 7 hr, thereafter significantly decreased in forestomach and corpus + antrum. Ouabain inhibited the H+ secretion, ulcer development, and stomach wall Mg2+-Na+-K+-dependent ATPase activity. The possible causal interrelationships between the examined parameters are studied.

Original languageEnglish
Pages (from-to)649-654
Number of pages6
JournalThe American Journal of Digestive Diseases
Volume21
Issue number8
DOIs
Publication statusPublished - Aug 1976

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Pylorus
Adenosine Diphosphate
Adenosine Triphosphatases
Stomach
Adenosine Triphosphate
Ligation
Ouabain
Stomach Ulcer
Ulcer

ASJC Scopus subject areas

  • Gastroenterology
  • Medicine(all)

Cite this

Examination of stomach wall Mg2+-Na+-K+-dependent ATPase, ATP, and ADP in pylorus-ligated rats. / Mózsik, G.; Vizi, F.

In: The American Journal of Digestive Diseases, Vol. 21, No. 8, 08.1976, p. 649-654.

Research output: Contribution to journalArticle

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