Examination of homogeneity with X-ray beams

Á Beretzky, K. Joó, I. Eros, K. Pintye-Hódi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The effects of blending time and rotation speed on the homogeneity of powder blends were examined. The concentrations of the samples were measured with an energy-dispersive X-ray fluorescence analyser, and control measurements were made with a UV spectrophotometer. The paired sample t-test showed that, for a large majority of the samples for which measurements were made to determine the concentrations, there was no essential difference. It may be stated, in accordance with the fitted equation, that the rotation speed and the square of the blending time exert significant effects on the distribution of the active ingredient. The energy-dispersive X-ray fluorescence analyser can be applied well for direct determination of the homogeneity of certain powder blends.

Original languageEnglish
Pages (from-to)155-159
Number of pages5
JournalInternational Journal of Pharmaceutics
Volume291
Issue number1-2
DOIs
Publication statusPublished - Mar 3 2005

Keywords

  • Full factorial design
  • Homogeneity
  • Powder blend
  • UV spectrophotometric analysis
  • X-ray fluorescence analysis

ASJC Scopus subject areas

  • Pharmaceutical Science

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