Examination of Hardy-Weinberg equilibrium in papers of Kidney International: An underused tool

István Kocsis, Balázs Györffy, Éva Németh, Barna Vásárhelyi

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Background. Population-genetic studies investigating genetic polymorphisms of Mendelian inheritance should always test whether the measured genotype frequencies deviate from the expected one. For this purpose Hardy-Weinberg (HW) criteria are generally used. If genotype distribution of control population misses HW equilibrium, the results should be treated cautiously because the observed genotype distribution in control population does not represent genotype distribution in the overall population. If HW criteria are not fulfilled in the investigated population, this may be further evidence for the correlation between genotype and investigated condition. Methods. Between September, 1998, and September, 2003, we tested papers published in Kidney International if HW criteria were ordinarily and correctly checked in studies investigating genetic polymorphisms. Seventy-five genotype distributions of the selected 39 articles were reanalyzed. Results. HW calculation was reportedly performed in 25 papers (64%). The observed genotype distribution deviated significantly from the expected one in three control, and in 16 patient populations and in three populations of association studies of 15 papers overall; however, this fact was not mentioned in 12 papers. Conclusion. Although the deviation of genotype distribution from the expected one is important information, HW calculations are not performed routinely for each investigated subject groups in these papers investigating genetic polymorphisms.

Original languageEnglish
Pages (from-to)1956-1958
Number of pages3
JournalKidney International
Volume65
Issue number5
DOIs
Publication statusPublished - May 2004

Keywords

  • Gene polymorphism
  • Hardy-Weinberg equilibrium
  • Population genetics

ASJC Scopus subject areas

  • Nephrology

Fingerprint Dive into the research topics of 'Examination of Hardy-Weinberg equilibrium in papers of Kidney International: An underused tool'. Together they form a unique fingerprint.

  • Cite this