Examination of claudin-1 expression in patients undergoing liver transplantation owing to hepatitis C virus cirrhosis

G. Zadori, F. Gelley, P. Torzsok, E. Sárváry, A. Doros, A. P. Deak, P. Nagy, Z. Schaff, A. Kiss, B. Nemes

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The cell adhesion molecule claudin-1 (CLDN-1) is a well known co-factor for the cell entry of hepatitis C virus (HCV). We examined 24 hepatic biopsies from liver transplant patients. Reverse transcriptase polymerase chain reaction (RT-PCR) and immunohistochemistry were performed according to standard procedures. RT-PCR results were shown as relative expression (ΔCT) with beta-actin as the reference gene. Immunohistochemistry results are shown by morphometry. The CLDN-1 mRNS expression rate was significantly lower when the patient displayed favorably with an unsatisfactory to antiviral therapy 0.756 ± 0.249 versus 1.304 ± 0.28 (P = .012). There was also a strong positive correlation between CLDN-1 protein expression and liver fibrosis (Pearson correlation coefficients: r = 0.476; P = .034).

Original languageEnglish
Pages (from-to)1267-1271
Number of pages5
JournalTransplantation Proceedings
Volume43
Issue number4
DOIs
Publication statusPublished - May 2011

Fingerprint

Claudin-1
Hepacivirus
Liver Transplantation
Fibrosis
Reverse Transcriptase Polymerase Chain Reaction
Immunohistochemistry
Claudins
Liver
Cell Adhesion Molecules
Liver Cirrhosis
Antiviral Agents
Actins
Transplants
Biopsy
Genes
Therapeutics

ASJC Scopus subject areas

  • Surgery
  • Transplantation

Cite this

Examination of claudin-1 expression in patients undergoing liver transplantation owing to hepatitis C virus cirrhosis. / Zadori, G.; Gelley, F.; Torzsok, P.; Sárváry, E.; Doros, A.; Deak, A. P.; Nagy, P.; Schaff, Z.; Kiss, A.; Nemes, B.

In: Transplantation Proceedings, Vol. 43, No. 4, 05.2011, p. 1267-1271.

Research output: Contribution to journalArticle

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