Evidence that somatostatin releases endogenous substance(s) responsible for its presynaptic inhibitory effect on rat vas deferens and guinea pig ileum

Elek Sylvester Vizi, Tamara Horváth, Georg Tamás Somogyi

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The ability of somatostatin to inhibit the muscular twitches elicited by field stimulation of rat vas deferens and guinea pig ileum was studied. Evidence should be summarized which would suggest that the presynaptic inhibitory effect of somatostatin on chemical neurotransmission is indirect. Its effect on vas deferens is partly mediated via α2-adrenoceptors and due to the released noradrenaline, in guinea pig ileum, however, it seems likely that it releases an unidentified inhibitory substance which, in fact, inhibits the release of acetylcholine, and thereby twitches of the ileum. The fast tachyphylaxis seen following repeated administration of the peptide is likely due to its indirect action.

Original languageEnglish
Pages (from-to)142-148
Number of pages7
JournalNeuroendocrinology
Volume39
Issue number2
DOIs
Publication statusPublished - Jan 1 1984

Keywords

  • Guinea pig ileum
  • Somatostatin
  • Vas deferens

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience

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