Evidence of the etiological predominance of norovirus in gastroenteritis outbreaks - Emerging new-variant and recombinant noroviruses in Hungary

G. Reuter, Katalin Krisztalovics, Harry Vennema, Marion Koopmans, György Szucs

Research output: Contribution to journalArticle

73 Citations (Scopus)

Abstract

Between January 2001 and December 2003, stool specimens from 262 (45%) of 581 reported outbreaks of gastroenteritis were investigated for noroviruses in Hungary. Specimens collected from outbreaks of non-bacterial gastroenteritis were examined by reverse-transcription polymerase chain reaction and enzyme immunoassay. In 253 (97%) of 262 outbreaks, norovirus was detected and confirmed by sequencing in 211 (81%). Hospitals (35%), day care centers (30%), and elderly homes (27%) were the most common settings. Diversity and frequency of the genotypes changed over time but with predominance (95%) of genogroup (GG) II strains. Strains grouped into 11 genotypes including an epidemic spread of new-variant GGII4 (Lordsdale virus) and a recently emerged group of natural recombinant strains (GGIIb/Hilversum polymerase) with four capsid types (Hawaii, Mexico, Snow Mountain, and Lordsdale). Clusters of epidemics including food-borne outbreaks were detected. According to this study, noroviruses are the predominant etiological agents causing gastroenteritis outbreaks in Hungary.

Original languageEnglish
Pages (from-to)598-607
Number of pages10
JournalJournal of Medical Virology
Volume76
Issue number4
DOIs
Publication statusPublished - Aug 2005

Fingerprint

Norovirus
Hungary
Gastroenteritis
Disease Outbreaks
Genotype
Snow
Capsid
Mexico
Immunoenzyme Techniques
Reverse Transcription
Viruses
Food
Polymerase Chain Reaction

Keywords

  • Calicivirus
  • Epidemiology
  • Gastroenteritis
  • GGII-4
  • Recombinant

ASJC Scopus subject areas

  • Virology

Cite this

Evidence of the etiological predominance of norovirus in gastroenteritis outbreaks - Emerging new-variant and recombinant noroviruses in Hungary. / Reuter, G.; Krisztalovics, Katalin; Vennema, Harry; Koopmans, Marion; Szucs, György.

In: Journal of Medical Virology, Vol. 76, No. 4, 08.2005, p. 598-607.

Research output: Contribution to journalArticle

Reuter, G. ; Krisztalovics, Katalin ; Vennema, Harry ; Koopmans, Marion ; Szucs, György. / Evidence of the etiological predominance of norovirus in gastroenteritis outbreaks - Emerging new-variant and recombinant noroviruses in Hungary. In: Journal of Medical Virology. 2005 ; Vol. 76, No. 4. pp. 598-607.
@article{8276da77030e4f598b1c0e033f5f3e35,
title = "Evidence of the etiological predominance of norovirus in gastroenteritis outbreaks - Emerging new-variant and recombinant noroviruses in Hungary",
abstract = "Between January 2001 and December 2003, stool specimens from 262 (45{\%}) of 581 reported outbreaks of gastroenteritis were investigated for noroviruses in Hungary. Specimens collected from outbreaks of non-bacterial gastroenteritis were examined by reverse-transcription polymerase chain reaction and enzyme immunoassay. In 253 (97{\%}) of 262 outbreaks, norovirus was detected and confirmed by sequencing in 211 (81{\%}). Hospitals (35{\%}), day care centers (30{\%}), and elderly homes (27{\%}) were the most common settings. Diversity and frequency of the genotypes changed over time but with predominance (95{\%}) of genogroup (GG) II strains. Strains grouped into 11 genotypes including an epidemic spread of new-variant GGII4 (Lordsdale virus) and a recently emerged group of natural recombinant strains (GGIIb/Hilversum polymerase) with four capsid types (Hawaii, Mexico, Snow Mountain, and Lordsdale). Clusters of epidemics including food-borne outbreaks were detected. According to this study, noroviruses are the predominant etiological agents causing gastroenteritis outbreaks in Hungary.",
keywords = "Calicivirus, Epidemiology, Gastroenteritis, GGII-4, Recombinant",
author = "G. Reuter and Katalin Krisztalovics and Harry Vennema and Marion Koopmans and Gy{\"o}rgy Szucs",
year = "2005",
month = "8",
doi = "10.1002/jmv.20403",
language = "English",
volume = "76",
pages = "598--607",
journal = "Journal of Medical Virology",
issn = "0146-6615",
publisher = "Wiley-Liss Inc.",
number = "4",

}

TY - JOUR

T1 - Evidence of the etiological predominance of norovirus in gastroenteritis outbreaks - Emerging new-variant and recombinant noroviruses in Hungary

AU - Reuter, G.

AU - Krisztalovics, Katalin

AU - Vennema, Harry

AU - Koopmans, Marion

AU - Szucs, György

PY - 2005/8

Y1 - 2005/8

N2 - Between January 2001 and December 2003, stool specimens from 262 (45%) of 581 reported outbreaks of gastroenteritis were investigated for noroviruses in Hungary. Specimens collected from outbreaks of non-bacterial gastroenteritis were examined by reverse-transcription polymerase chain reaction and enzyme immunoassay. In 253 (97%) of 262 outbreaks, norovirus was detected and confirmed by sequencing in 211 (81%). Hospitals (35%), day care centers (30%), and elderly homes (27%) were the most common settings. Diversity and frequency of the genotypes changed over time but with predominance (95%) of genogroup (GG) II strains. Strains grouped into 11 genotypes including an epidemic spread of new-variant GGII4 (Lordsdale virus) and a recently emerged group of natural recombinant strains (GGIIb/Hilversum polymerase) with four capsid types (Hawaii, Mexico, Snow Mountain, and Lordsdale). Clusters of epidemics including food-borne outbreaks were detected. According to this study, noroviruses are the predominant etiological agents causing gastroenteritis outbreaks in Hungary.

AB - Between January 2001 and December 2003, stool specimens from 262 (45%) of 581 reported outbreaks of gastroenteritis were investigated for noroviruses in Hungary. Specimens collected from outbreaks of non-bacterial gastroenteritis were examined by reverse-transcription polymerase chain reaction and enzyme immunoassay. In 253 (97%) of 262 outbreaks, norovirus was detected and confirmed by sequencing in 211 (81%). Hospitals (35%), day care centers (30%), and elderly homes (27%) were the most common settings. Diversity and frequency of the genotypes changed over time but with predominance (95%) of genogroup (GG) II strains. Strains grouped into 11 genotypes including an epidemic spread of new-variant GGII4 (Lordsdale virus) and a recently emerged group of natural recombinant strains (GGIIb/Hilversum polymerase) with four capsid types (Hawaii, Mexico, Snow Mountain, and Lordsdale). Clusters of epidemics including food-borne outbreaks were detected. According to this study, noroviruses are the predominant etiological agents causing gastroenteritis outbreaks in Hungary.

KW - Calicivirus

KW - Epidemiology

KW - Gastroenteritis

KW - GGII-4

KW - Recombinant

UR - http://www.scopus.com/inward/record.url?scp=21744449962&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=21744449962&partnerID=8YFLogxK

U2 - 10.1002/jmv.20403

DO - 10.1002/jmv.20403

M3 - Article

C2 - 15977235

AN - SCOPUS:21744449962

VL - 76

SP - 598

EP - 607

JO - Journal of Medical Virology

JF - Journal of Medical Virology

SN - 0146-6615

IS - 4

ER -