Evidence of significant synergism between antibiotics and the antipsychotic, antimicrobial drug flupenthixol

L. Jeyaseeli, A. Dasgupta, S. G. Dastidar, J. Molnár, L. Amaral

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Previously, the antipsychotic, non-antibiotic compound flupenthixol dihydrochloride (Fp) was shown to exhibit distinct in vitro antibacterial activity against Gram-positive and Gram-negative bacteria and to significantly protect Swiss albino mice challenged with a known mouse virulent salmonella. The present study was designed to ascertain whether this drug could efficiently augment the action of an antibiotic or a non-antibiotic when tested in combination. A total of 12 bacterial strains belonging to various genera were selected for this study and were sensitive to the antibiotics penicillin (Pc), ampicillin, chloramphenicol, tetracycline, streptomycin, gentamicin, erythromycin, ciprofloxacin, and to the non-antibiotics methdilazine, triflupromazine, promethazine, and Fp. Pronounced and statistically significant synergism (p

Original languageEnglish
Pages (from-to)1243-1250
Number of pages8
JournalEuropean Journal of Clinical Microbiology and Infectious Diseases
Volume31
Issue number6
DOIs
Publication statusPublished - Jun 2012

Fingerprint

Flupenthixol
Antipsychotic Agents
Triflupromazine
Anti-Bacterial Agents
Promethazine
Streptomycin
Chloramphenicol
Erythromycin
Ampicillin
Ciprofloxacin
Gentamicins
Tetracycline
Gram-Negative Bacteria
Salmonella
Penicillins
Pharmaceutical Preparations
methdilazine
In Vitro Techniques

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Medicine(all)

Cite this

Evidence of significant synergism between antibiotics and the antipsychotic, antimicrobial drug flupenthixol. / Jeyaseeli, L.; Dasgupta, A.; Dastidar, S. G.; Molnár, J.; Amaral, L.

In: European Journal of Clinical Microbiology and Infectious Diseases, Vol. 31, No. 6, 06.2012, p. 1243-1250.

Research output: Contribution to journalArticle

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