Evidence of parthenogenetic origin of ovarian teratoma: Case report

Flávio Garcia Oliveira, Dmitri Dozortsev, Michael Peter Diamond, Adriana Fracasso, Soraya Abdelmassih, Vicente Abdelmassih, Sergio Pereira Gonçalves, Roger Abdelmassih, Zolt Peter Nagy

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Abstract

This case report represents one of the few documented cases of parthenote embryo retrieval from an IVF patient with a history of ovarian teratomas. A 29-year-old woman presented at our centre with a history of primary infertility for 6 years due to male factor. She had undergone left oophorectomy 4 years before due to an ovarian teratoma. An ultrasound scan performed during basal evaluation revealed two complex images in the right ovary suggesting teratomas, measuring 2.5 × 2.4 and 1.7 × 1.3 cm. A significant extent of sonographically normal ovarian parenchyma was present, and the patient underwent the long leuprolide acetate protocol of ovarian stimulation with recombinant FSH for an IVF-ICSI cycle. She had 13 metaphase II (MII), four metaphase I (MI), two germinal vesicle (GV) oocytes and one 4-cell embryo retrieved. Eight out of nine injected oocytes were fertilized normally while one was unfertilized. Embryo transfer was carried out 72 h after retrieval. The 4-cell (parthenote) embryo recovered at oocyte retrieval continued to cleave in culture, developing into a 7-cell embryo by the next. day. The embryo was morphologically normal, presenting an evident nucleus in each blastomere. Fluorescent in situ hybridization (FISH) returned two signals for the X chromosome in each blastomere that was analysed. Of the eight normally fertilized embryos, three were transferred, resulting in a normal singleton pregnancy and the birth of a healthy baby.

Original languageEnglish
Pages (from-to)1867-1870
Number of pages4
JournalHuman Reproduction
Volume19
Issue number8
DOIs
Publication statusPublished - Aug 2004

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Keywords

  • Embryo
  • FISH
  • IVF-ICSI
  • Ovarian teratoma
  • Parthenogenetic oocyte activation

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Garcia Oliveira, F., Dozortsev, D., Diamond, M. P., Fracasso, A., Abdelmassih, S., Abdelmassih, V., Gonçalves, S. P., Abdelmassih, R., & Nagy, Z. P. (2004). Evidence of parthenogenetic origin of ovarian teratoma: Case report. Human Reproduction, 19(8), 1867-1870. https://doi.org/10.1093/humrep/deh345