Evidence for the presence of a low molecular-weight activator of suppressor monocytes (LASM) of dialysates of T lymphocytes

K. Nékám, A. J. Strelkauskas, H. H. Fudenberg, G. G. Donnan, J. M. Goust

Research output: Contribution to journalArticle

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Abstract

Lysates of peripheral blood T lymphocytes from healthy individuals were found to contain a low molecular-weight peptide that inhibited phyto-haemagglutinin-induced DNA synthesis in vitro by autologous or allogeneic peripheral blood mononuclear cells. The peptide was dialysable, partially heat stable, resistant to trypsin, RNase, and DNase but not to pronase, and was not part of the membrane receptor involved in rosette formation by T lymphocytes with sheep erythrocytes. It was found to act through monocytes, inducing the synthesis of second mediator responsible for the inhibition of lymphocyte DNA synthesis. This inducer of inhibition, designated as 'low molecular-weight activator of suppressor monocytes' (LASM), may have a role in the depression of cellular immune response seen in various pathological conditions involving the destruction of T lymphocytes.

Original languageEnglish
Pages (from-to)75-80
Number of pages6
JournalImmunology
Volume43
Issue number1
Publication statusPublished - 1981

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Dialysis Solutions
Monocytes
Molecular Weight
T-Lymphocytes
Rosette Formation
Pronase
Peptides
Deoxyribonucleases
DNA
Hemagglutinins
Ribonucleases
Cellular Immunity
Trypsin
Blood Cells
Sheep
Hot Temperature
Erythrocytes
Lymphocytes
Membranes

ASJC Scopus subject areas

  • Immunology

Cite this

Nékám, K., Strelkauskas, A. J., Fudenberg, H. H., Donnan, G. G., & Goust, J. M. (1981). Evidence for the presence of a low molecular-weight activator of suppressor monocytes (LASM) of dialysates of T lymphocytes. Immunology, 43(1), 75-80.

Evidence for the presence of a low molecular-weight activator of suppressor monocytes (LASM) of dialysates of T lymphocytes. / Nékám, K.; Strelkauskas, A. J.; Fudenberg, H. H.; Donnan, G. G.; Goust, J. M.

In: Immunology, Vol. 43, No. 1, 1981, p. 75-80.

Research output: Contribution to journalArticle

Nékám, K, Strelkauskas, AJ, Fudenberg, HH, Donnan, GG & Goust, JM 1981, 'Evidence for the presence of a low molecular-weight activator of suppressor monocytes (LASM) of dialysates of T lymphocytes', Immunology, vol. 43, no. 1, pp. 75-80.
Nékám, K. ; Strelkauskas, A. J. ; Fudenberg, H. H. ; Donnan, G. G. ; Goust, J. M. / Evidence for the presence of a low molecular-weight activator of suppressor monocytes (LASM) of dialysates of T lymphocytes. In: Immunology. 1981 ; Vol. 43, No. 1. pp. 75-80.
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