Evidence for the involvement of substance P in the atropine-resistant peristalsis of the guinea-pig ileum

L. Barthó, P. Holzer, J. Donnerer, F. Lembeck

Research output: Contribution to journalArticle

66 Citations (Scopus)

Abstract

In the isolated, vascularly perfused guinea-pig ileum, peristalsis could be induced by raising the intraluminal pressure in the presence of atropine. Atropine-resistant peristalsis was greatly inhibited or abolished by the substance P antagonist (d-Pro2, d-Trp7,9)-substance P, substance P desensitization, hexamethonium and by the enkephalin analogue FK 33-824. It is concluded that substance P neurones of the intestine play an important role in the atropine-resistant peristalsis of the guinea-pig ileum.

Original languageEnglish
Pages (from-to)69-74
Number of pages6
JournalNeuroscience Letters
Volume32
Issue number1
DOIs
Publication statusPublished - Sep 20 1982

Fingerprint

Peristalsis
Substance P
Atropine
Ileum
Guinea Pigs
D-Ala(2),MePhe(4),Met(0)-ol-enkephalin
Hexamethonium
Enkephalins
Intestines
Neurons
Pressure

Keywords

  • atropine-resistant peristalsis
  • enkephalin analogue
  • guinea-pig ileum
  • substance P
  • substance P antagonist

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Evidence for the involvement of substance P in the atropine-resistant peristalsis of the guinea-pig ileum. / Barthó, L.; Holzer, P.; Donnerer, J.; Lembeck, F.

In: Neuroscience Letters, Vol. 32, No. 1, 20.09.1982, p. 69-74.

Research output: Contribution to journalArticle

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