Evidence for the involvement of P2-purinoceptors in the cholinergic contraction of the guinea-pig ileum

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Abstract

In the isolated ileum of the guinea-pig the P2-purinoceptor antagonists PPADS and suramin: (a) strongly inhibited the cholinergic contractile effect of α,β-methylene ATP, (b) did not influence contractions evoked by exogenous acetylcholine (ACh) but, (c) moderately (by about 30%) inhibited cholinergic contractions due to electrical field stimulation (EFS), in a non-additive manner. These results suggest that an endogenous ligand that stimulates P2-purinoceptors (possibly ATP) is involved in the contractile effect of EFS, as a positive modulator of ACh release.

Original languageEnglish
Pages (from-to)1507-1508
Number of pages2
JournalBritish journal of pharmacology
Volume121
Issue number8
DOIs
Publication statusPublished - Aug 27 1997

Keywords

  • Acetylcholine release
  • Intestine
  • P-purinoceptors
  • PPADS
  • Suramin
  • α,β-methylene ATP

ASJC Scopus subject areas

  • Pharmacology

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