Evidence for the involvement of P2-purinoceptors in the cholinergic contraction of the guinea-pig ileum

L. Barthó, L. Lénárd, Carlo A. Maggi

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

In the isolated ileum of the guinea-pig the P2-purinoceptor antagonists PPADS and suramin: (a) strongly inhibited the cholinergic contractile effect of α,β-methylene ATP, (b) did not influence contractions evoked by exogenous acetylcholine (ACh) but, (c) moderately (by about 30%) inhibited cholinergic contractions due to electrical field stimulation (EFS), in a non-additive manner. These results suggest that an endogenous ligand that stimulates P2-purinoceptors (possibly ATP) is involved in the contractile effect of EFS, as a positive modulator of ACh release.

Original languageEnglish
Pages (from-to)1507-1508
Number of pages2
JournalBritish Journal of Pharmacology
Volume121
Issue number8
DOIs
Publication statusPublished - 1997

Fingerprint

Purinergic P2 Receptors
Ileum
Cholinergic Agents
Electric Stimulation
Acetylcholine
Purinergic P2 Receptor Antagonists
Guinea Pigs
Adenosine Triphosphate
Suramin
Ligands
pyridoxal phosphate-6-azophenyl-2',4'-disulfonic acid

Keywords

  • α,β-methylene ATP
  • Acetylcholine release
  • Intestine
  • P-purinoceptors
  • PPADS
  • Suramin

ASJC Scopus subject areas

  • Pharmacology

Cite this

Evidence for the involvement of P2-purinoceptors in the cholinergic contraction of the guinea-pig ileum. / Barthó, L.; Lénárd, L.; Maggi, Carlo A.

In: British Journal of Pharmacology, Vol. 121, No. 8, 1997, p. 1507-1508.

Research output: Contribution to journalArticle

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