Evidence for plastic processes in migraine with aura: A diffusion weighted MRI study

Nikoletta Szabó, Péter Faragó, András Király, Dániel Veréb, Gergő Csete, Eszter Tóth, Krisztián Kocsis, Bálint Kincses, Bernadett Tuka, A. Párdutz, Délia Szok, J. Tajti, L. Vécsei, Zsigmond T. Kincses

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background: Formerly white matter abnormalities in a mixed group of migraine patients with and without aura were shown. Here, we aimed to explore white matter alterations in a homogeneous group of migraineurs with aura and to delineate possible relationships between white matter changes and clinical variables. Methods: Eighteen patients with aura, 25 migraine patients without aura and 28 controls were scanned on a 1.5T MRI scanner. Diffusivity parameters of the white matter were estimated and compared between patients’ groups and controls using whole-brain tract-based spatial statistics. Results: Decreased radial diffusivity (p < 0.036) was found bilaterally in the parieto-occipital white matter, the corpus callosum, and the cingular white matter of migraine with aura (MwA) patients compared to controls. Migraine without aura (MwoA) patients showed no alteration compared to controls. MwA compared to MwoA showed increased fractional anisotropy (p < 0.048) in the left parieto-occipital white matter. In MwA a negative correlation was found between axial diffusivity and disease duration in the left superior longitudinal fascicle (left parieto-occipital region) and in the left corticospinal tract (p < 0.036) and with the number of the attacks in the right superior longitudinal fascicle (p < 0.048). Conclusion: We showed for the first time that there are white matter microstructural differences between these two subgroups of migraine and hence it is important to handle the two groups separately in further researches. We propose that degenerative and maladaptive plastic changes coexist in the disease and the diffusion profile is a result of these processes.

Original languageEnglish
Article number138
JournalFrontiers in Neuroanatomy
Volume11
DOIs
Publication statusPublished - Jan 17 2018

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Migraine with Aura
Diffusion Magnetic Resonance Imaging
Migraine without Aura
Epilepsy
Occipital Lobe
Pyramidal Tracts
White Matter
Corpus Callosum
Anisotropy
Migraine Disorders
Control Groups
Brain

Keywords

  • DTI
  • Microstructure
  • Neurodegeneration
  • Plasticity
  • TBSS
  • White matter

ASJC Scopus subject areas

  • Anatomy
  • Neuroscience (miscellaneous)
  • Cellular and Molecular Neuroscience

Cite this

Szabó, N., Faragó, P., Király, A., Veréb, D., Csete, G., Tóth, E., ... Kincses, Z. T. (2018). Evidence for plastic processes in migraine with aura: A diffusion weighted MRI study. Frontiers in Neuroanatomy, 11, [138]. https://doi.org/10.3389/fnana.2017.00138

Evidence for plastic processes in migraine with aura : A diffusion weighted MRI study. / Szabó, Nikoletta; Faragó, Péter; Király, András; Veréb, Dániel; Csete, Gergő; Tóth, Eszter; Kocsis, Krisztián; Kincses, Bálint; Tuka, Bernadett; Párdutz, A.; Szok, Délia; Tajti, J.; Vécsei, L.; Kincses, Zsigmond T.

In: Frontiers in Neuroanatomy, Vol. 11, 138, 17.01.2018.

Research output: Contribution to journalArticle

Szabó, N, Faragó, P, Király, A, Veréb, D, Csete, G, Tóth, E, Kocsis, K, Kincses, B, Tuka, B, Párdutz, A, Szok, D, Tajti, J, Vécsei, L & Kincses, ZT 2018, 'Evidence for plastic processes in migraine with aura: A diffusion weighted MRI study', Frontiers in Neuroanatomy, vol. 11, 138. https://doi.org/10.3389/fnana.2017.00138
Szabó, Nikoletta ; Faragó, Péter ; Király, András ; Veréb, Dániel ; Csete, Gergő ; Tóth, Eszter ; Kocsis, Krisztián ; Kincses, Bálint ; Tuka, Bernadett ; Párdutz, A. ; Szok, Délia ; Tajti, J. ; Vécsei, L. ; Kincses, Zsigmond T. / Evidence for plastic processes in migraine with aura : A diffusion weighted MRI study. In: Frontiers in Neuroanatomy. 2018 ; Vol. 11.
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