Evidence for genetic variability in venous responsiveness

Z. Vajó, B. Székács, W. Dachman

Research output: Contribution to journalArticle

Abstract

Alterations in adrenergic mediated vascular responsiveness and glucose metabolism have been implicated in the pathogenesis of essential hypertension. We sought for a human model to study possible interactions between the two pathogenetical factors. In a group of Latin-Americans there is a predominance of diabetes mellitus, impaired glucose tolerance and obesity, while the rate of hypertension is unexpectedly low (lower than in the normal population). Here we demonstrate attenuated alpha] adrenergic mediated vasoconstriction in the above group, suggesting a possible protective mechanism against the development hypertension.

Original languageEnglish
Pages (from-to)353-360
Number of pages8
JournalActa Physiologica Hungarica
Volume84
Issue number4
Publication statusPublished - 1996

Fingerprint

Adrenergic Agents
Hypertension
Glucose Intolerance
Vasoconstriction
Blood Vessels
Diabetes Mellitus
Obesity
Glucose
Population
Essential Hypertension

Keywords

  • Essential hypertension
  • Glucose metabolism
  • Vascular responsiveness

ASJC Scopus subject areas

  • Physiology

Cite this

Evidence for genetic variability in venous responsiveness. / Vajó, Z.; Székács, B.; Dachman, W.

In: Acta Physiologica Hungarica, Vol. 84, No. 4, 1996, p. 353-360.

Research output: Contribution to journalArticle

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