Evidence for direct cellular protective effect of PL-10 substances (Synthesized parts of body protection compound, BPC) and their specificity to gastric mucosal cells

Beáta Bódis, Oszká Karádi, Péter Németh, Csaba Dohoczky, Marko Kolega, Gyula Mózsik

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The direct gastric mucosal cellular effect of four PL-10 substance (a synthesized part of human body protection compound, BPC containing 14 or 15 amino acids) was studied on freshly isolated rat gastric mucosal cells and on mouse myeloma cell line (Sp2/0-Ag14) in an ethanol-induced cell injury model. The examined substances were not toxic for the cells. Two of them proved to be significantly protective against the direct cellular damaging effect of ethanol (PL 10.1.15AK-3 in 5 μg/ml dose and PL 10.1.AK14-2 dose-dependently, ED50=50 ng/ml) on gastric mucosal cells. This cytoprotective effect was failured on mouse myeloma cells. Based on these results a part of the in vivo protection induced by BPC seems to be a direct cellular protective effect to gastric mucosal cells.

Original languageEnglish
Pages (from-to)PL243
JournalLife sciences
Volume61
Issue number16
DOIs
Publication statusPublished - Sep 12 1997

Keywords

  • Body protection compound
  • Direct cytoprotection
  • Isolated rat gastric mucosal cells
  • PL-10 substances

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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