Evidence for an antagonist specific receptor that does not bind mineralocorticoid agonists

G. Lazar, M. K. Agarwal

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Kinetics of association - dissociation, competition and chromatography on two different resins, all revealed the presence of a new binding site which: specifically accepts 7-alpha-propyl spirolactone (3H-RU-26752), has little affinity for aldosterone, is present only in the target tissue (rat kidney), and is wanting in a non-target organ (liver). The presence of such sites could explain syndromes of mineralocorticoid excess where even trace amounts of an unusual aldosterone analogue, with little affinity for the classical mineralocorticoid receptor, can nevertheless produce hypertension through the intervention of an entirely new and abundant receptor system. This new molecule thus forms a novel tool to understand the nature and function of the soluble mineralocorticoid receptor in target organs.

Original languageEnglish
Pages (from-to)261-265
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume134
Issue number1
DOIs
Publication statusPublished - Jan 14 1986

Fingerprint

Mineralocorticoid Receptors
Mineralocorticoids
Aldosterone
Spironolactone
Chromatography
Liver
Rats
Resins
Binding Sites
Association reactions
Tissue
Hypertension
Kidney
Molecules
Kinetics
7-propyl spirolactone

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Evidence for an antagonist specific receptor that does not bind mineralocorticoid agonists. / Lazar, G.; Agarwal, M. K.

In: Biochemical and Biophysical Research Communications, Vol. 134, No. 1, 14.01.1986, p. 261-265.

Research output: Contribution to journalArticle

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