Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model

Ágnes Bánvölgyi, L. Pálinkás, T. Berki, Natalie Clark, Andrew D. Grant, Z. Helyes, G. Pozsgai, J. Szolcsányi, Susan D. Brain, E. Pintér

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

The purpose of this study was to examine the involvement of the transient receptor potential vanilloid receptor 1 (TRPV1) in inflammatory processes observed in murine allergic contact dermatitis (ACD). Oxazolone-induced ACD evoked a significant ear swelling after 24-72 h. It was augmented in TRPV1 knockout mice at all time points and supported by histological analysis and measure of TNF-α. However, tissue swelling and cytokine generation was significantly reduced in both neurokinin 1 receptor and calcitonin gene-related peptide (CGRP) knockout mice. A protective involvement of the TRPV1 receptor was identified of contact dermatitis distinct from mechanisms involving the major pro-inflammatory neuropeptides.

Original languageEnglish
Pages (from-to)86-96
Number of pages11
JournalJournal of Neuroimmunology
Volume169
Issue number1-2
DOIs
Publication statusPublished - Dec 2005

Fingerprint

TRPV Cation Channels
Allergic Contact Dermatitis
Knockout Mice
Skin
Oxazolone
Neurokinin-1 Receptors
Calcitonin Gene-Related Peptide
Contact Dermatitis
Neuropeptides
Ear
Cytokines
vanilloid receptor subtype 1

Keywords

  • Inflammation
  • Neuropeptides
  • Skin
  • Transgenic/knockout
  • TRPV1

ASJC Scopus subject areas

  • Immunology
  • Clinical Neurology
  • Immunology and Allergy
  • Neurology

Cite this

Evidence for a novel protective role of the vanilloid TRPV1 receptor in a cutaneous contact allergic dermatitis model. / Bánvölgyi, Ágnes; Pálinkás, L.; Berki, T.; Clark, Natalie; Grant, Andrew D.; Helyes, Z.; Pozsgai, G.; Szolcsányi, J.; Brain, Susan D.; Pintér, E.

In: Journal of Neuroimmunology, Vol. 169, No. 1-2, 12.2005, p. 86-96.

Research output: Contribution to journalArticle

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