Evidence for a direct peripheral effect of clonidine on the norepinephrine release in vivo in pithed rats

Katalin Szemeredi, Zofia Zukowska-Grojec, G. Bagdy, James Hill, Irwin J. Kopin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

To study in vivo peripheral effects of clonidine on sympathetic neuronal function we measured, after different doses of clonidine, plasma norepinephrine (NE) and blood pressure (BP) responses during electric stimulation of sympathetic outflow in pithed male Sprague-Dawley rats. In this preparation, clonidine produced dose-dependent inhibition of the sympathetic stimulation-induced pressor and plasma NE responses. The dose of clonidine inhibiting the NE response by 50% (ID50) was 14.2 ± 0.3 μg/kg i.v., while ID50 for the diastolic pressor response was 22.0 ± 0.2 μg/kg i.v. Since clonidine did not alter the relationship between NE released into the plasma and the pressor responses, the entire effect of clonidine in decreasing the pressor response to sympathetic stimulation may be attributed to its presynaptic α2-adrenoceptor-mediated inhibition of NE release.

Original languageEnglish
Pages (from-to)251-255
Number of pages5
JournalEuropean Journal of Pharmacology
Volume145
Issue number3
DOIs
Publication statusPublished - Jan 19 1988

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Clonidine
Norepinephrine
Adrenergic Receptors
Electric Stimulation
Sprague Dawley Rats
Blood Pressure

Keywords

  • (Presynaptic)
  • Clonidine
  • Pithed rat
  • Plasma norepinephrine
  • α-Adrenoceptors

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience
  • Pharmacology

Cite this

Evidence for a direct peripheral effect of clonidine on the norepinephrine release in vivo in pithed rats. / Szemeredi, Katalin; Zukowska-Grojec, Zofia; Bagdy, G.; Hill, James; Kopin, Irwin J.

In: European Journal of Pharmacology, Vol. 145, No. 3, 19.01.1988, p. 251-255.

Research output: Contribution to journalArticle

Szemeredi, Katalin ; Zukowska-Grojec, Zofia ; Bagdy, G. ; Hill, James ; Kopin, Irwin J. / Evidence for a direct peripheral effect of clonidine on the norepinephrine release in vivo in pithed rats. In: European Journal of Pharmacology. 1988 ; Vol. 145, No. 3. pp. 251-255.
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