Evaluation of the swelling behaviour of iota-carrageenan in monolithic matrix tablets

András Kelemen, Gyula Buchholcz, Tamás Sovány, Klára Pintye-Hódi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The swelling properties of monolithic matrix tablets containing iota-carrageenan were studied at different pH values, with measurements of the swelling force and characterization of the profile of the swelling curve. The swelling force meter was linked to a PC by an RS232 cable and the measured data were evaluated with self-developed software. The monitor displayed the swelling force vs. time curve with the important parameters, which could be fitted with an Analysis menu. In the case of iota-carrageenan matrix tablets, it was concluded that the pH and the pressure did not influence the swelling process, and the first section of the swelling curve could be fitted by the Korsmeyer-Peppas equation.

Original languageEnglish
Pages (from-to)85-88
Number of pages4
JournalJournal of Pharmaceutical and Biomedical Analysis
Volume112
DOIs
Publication statusPublished - Aug 1 2015

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Keywords

  • Biodegradable polymer
  • Biomaterials
  • Iota-carrageenan
  • Monolithic matrix tablet
  • Swelling force meter
  • Swelling kinetics

ASJC Scopus subject areas

  • Analytical Chemistry
  • Pharmaceutical Science
  • Drug Discovery
  • Spectroscopy
  • Clinical Biochemistry

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