Evaluation of the metabolic changes during hemodialysis by signal averaged ECG

E. Berta, A. Erdei, B. Cseke, A. Gazdag, G. Paragh, J. Balla, P. Polgar, E. Nagy, Miklos Bodor

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Abstract

Cardiovascular diseases are frequent complications of end-stage kidney disease. The aim of the present study was to prove the arrhythmogenic effect of dialysis using signal averaged ECG. The ECG changes and laboratory parameters (sodium, potassium, urea and creatinine levels) were detected during hemodialysis treatment in 26 patients suffering from end-stage kidney disease. The tests and the ECG were performed four times, before (0. minute), during (at 15 and 90 min), and eventually after dialysis (at 240 min). The duration of the QRS complex, high-frequency low-amplitude signals (HFLA), and root-mean-square voltage of the terminal 40 ms of the filtered QRS (RMS) were determined. We considered test results to be positive when two of the three tested parameters were outside the normal range: QRS> 120 ms, RMS<20 uV, HFLA > 39ms. Signal averaged ECG was positive in two cases (8%) before and after the dialysis. The duration of the QRS-complex increased significantly during the dialysis (predialysis: 109 ± 7.6 ms, postdialysis: 116 ± 8.0 ms, p <0.0001). Serum urea nitrogen (predialysis: 26.2 ± 5.4, postdialysis: 11.4 ± 3.3 mmol/l, p <0.0001) and serum creatinine levels (predialysis: 931 ± 212, postdialysis: 434 ± 120 μmol/l, p

Original languageEnglish
Pages (from-to)380-383
Number of pages4
JournalPharmazie
Volume67
Issue number5
DOIs
Publication statusPublished - 2012

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Renal Dialysis
Dialysis
Electrocardiography
Chronic Kidney Failure
Urea
Creatinine
Serum
Potassium
Reference Values
Cardiovascular Diseases
Nitrogen
Sodium
Therapeutics

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Evaluation of the metabolic changes during hemodialysis by signal averaged ECG. / Berta, E.; Erdei, A.; Cseke, B.; Gazdag, A.; Paragh, G.; Balla, J.; Polgar, P.; Nagy, E.; Bodor, Miklos.

In: Pharmazie, Vol. 67, No. 5, 2012, p. 380-383.

Research output: Contribution to journalArticle

Berta, E, Erdei, A, Cseke, B, Gazdag, A, Paragh, G, Balla, J, Polgar, P, Nagy, E & Bodor, M 2012, 'Evaluation of the metabolic changes during hemodialysis by signal averaged ECG', Pharmazie, vol. 67, no. 5, pp. 380-383. https://doi.org/10.1691/ph.2012.1692
Berta, E. ; Erdei, A. ; Cseke, B. ; Gazdag, A. ; Paragh, G. ; Balla, J. ; Polgar, P. ; Nagy, E. ; Bodor, Miklos. / Evaluation of the metabolic changes during hemodialysis by signal averaged ECG. In: Pharmazie. 2012 ; Vol. 67, No. 5. pp. 380-383.
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