Evaluation of the Malnutrition-Inflammation Score in Kidney Transplant Recipients

M. Molnár, Andras Keszei, Maria Eszter Czira, Anna Rudas, Akos Ujszaszi, Bela Haromszeki, J. Kósa, P. Lakatos, E. Sárváry, G. Bekő, Katalin Fornadi, Istvan Kiss, A. Remport, M. Novák, Kamyar Kalantar-Zadeh, Csaba P. Kovesdy, I. Mucsi

Research output: Contribution to journalArticle

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Abstract

Background: Chronic protein-energy wasting, termed malnutrition-inflammation complex syndrome, is frequent in patients with chronic kidney disease and is associated with anemia, morbidity, and mortality in patients on maintenance dialysis therapy. The Malnutrition-Inflammation Score (MIS) recently has been developed and validated in dialysis patients. Study Design: Observational cross-sectional study. Setting & Participants: 993 prevalent kidney transplant recipients. Predictor: MIS computed from change in body weight, dietary intake, gastrointestinal symptoms, functional capacity, comorbid conditions, decreased fat store/Systemic Global Assessment, signs of muscle wasting/Systemic Global Assessment, body mass index, serum albumin level, and serum transferrin level. Outcomes: Markers of inflammation and malnutrition, including serum C-reactive protein, interleukin 6, tumor necrosis factor α, serum leptin, prealbumin, body mass index, and abdominal circumference. The relationship was modeled by using structural equation models. Results: Mean age was 51 ± 13 years, 57% were men, and 21% had diabetes. Median time from transplant was 72 months. MIS significantly correlated with abdominal circumference (r = -0.144), serum C-reactive protein level (r = 0.094), serum interleukin 6 level (r = 0.231), and serum tumor necrosis factor α level (r = 0.102; P <0.01 for all). A structural equation model with 2 latent variables (malnutrition and inflammation factor) showed good fit to the observed data. Limitations: Single-center study, lack of information about vascular access, presence of nonfunctioning kidney transplant, relatively high refusal rate. Conclusions: Our results confirm that MIS reflects both energy-protein wasting and inflammation in kidney transplant recipients. This simple instrument appears to be a useful tool to assess the presence of protein-energy wasting in this patient population.

Original languageEnglish
Pages (from-to)102-111
Number of pages10
JournalAmerican Journal of Kidney Diseases
Volume56
Issue number1
DOIs
Publication statusPublished - Jul 2010

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Malnutrition
Inflammation
Kidney
Structural Models
Serum
C-Reactive Protein
Blood Proteins
Dialysis
Interleukin-6
Body Mass Index
Tumor Necrosis Factor-alpha
Transplants
Body Weight Changes
Proteins
Prealbumin
Transplant Recipients
Transferrin
Leptin
Chronic Renal Insufficiency
Serum Albumin

Keywords

  • Kidney transplant
  • Malnutrition-Inflammation Score
  • protein-energy wasting
  • validation

ASJC Scopus subject areas

  • Nephrology

Cite this

Evaluation of the Malnutrition-Inflammation Score in Kidney Transplant Recipients. / Molnár, M.; Keszei, Andras; Czira, Maria Eszter; Rudas, Anna; Ujszaszi, Akos; Haromszeki, Bela; Kósa, J.; Lakatos, P.; Sárváry, E.; Bekő, G.; Fornadi, Katalin; Kiss, Istvan; Remport, A.; Novák, M.; Kalantar-Zadeh, Kamyar; Kovesdy, Csaba P.; Mucsi, I.

In: American Journal of Kidney Diseases, Vol. 56, No. 1, 07.2010, p. 102-111.

Research output: Contribution to journalArticle

Molnár, M. ; Keszei, Andras ; Czira, Maria Eszter ; Rudas, Anna ; Ujszaszi, Akos ; Haromszeki, Bela ; Kósa, J. ; Lakatos, P. ; Sárváry, E. ; Bekő, G. ; Fornadi, Katalin ; Kiss, Istvan ; Remport, A. ; Novák, M. ; Kalantar-Zadeh, Kamyar ; Kovesdy, Csaba P. ; Mucsi, I. / Evaluation of the Malnutrition-Inflammation Score in Kidney Transplant Recipients. In: American Journal of Kidney Diseases. 2010 ; Vol. 56, No. 1. pp. 102-111.
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AU - Ujszaszi, Akos

AU - Haromszeki, Bela

AU - Kósa, J.

AU - Lakatos, P.

AU - Sárváry, E.

AU - Bekő, G.

AU - Fornadi, Katalin

AU - Kiss, Istvan

AU - Remport, A.

AU - Novák, M.

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