A pantoprazol és a ranitidin hatékonyságának vizsgálata nyombélfekély kezelésére. Nemzetközi multicentrikus vizsgálat eredménye.

Translated title of the contribution: Evaluation of the effectiveness of pantoprazole and ranitidine in the treatment of duodenal ulcer. Result of an international multicenter study

J. Papp, Z. Döbrönte, L. Juhász, J. Lonovics

Research output: Contribution to journalArticle

Abstract

A double-blind, randomized, multicenter, multicountry study (Poland, Chech Republic, Hungary) was carried out in 1995 on patients (n = 326) with endoscopically confirmed duodenal ulcer treated with ranitidine vs. pantoprazole. In Hungary-in 4 gastroenterology centers-123 patients have been involved (age 18-75 years). The treatment schedule has been 300 mgs of ranitidine or 40 mgs of pantoprazole q. d. for 2 or if necessary for 4 weeks. In the Hungarian study 60 DU patients were treated with pantoprazole vs. 63 ones with ranitidine. Having finished the two-week schedule the healing rates of duodenal ulcer were as follows: pantoprazole 71%/72% (Hungary/International) vs ranitidine 57%/51%, (p < 0.001). After 4 weeks the corresponding values showed the following: pantoprazole 98%/94% vs. ranitidine 88%/86%, respectively, (p < 0.005). Both drugs have shown to be effective and safe to cure duodenal ulcer however in our study pantoprazole was significantly more efficacious and provided quicker healing than ranitidine.

Translated title of the contributionEvaluation of the effectiveness of pantoprazole and ranitidine in the treatment of duodenal ulcer. Result of an international multicenter study
Original languageHungarian
Pages (from-to)2863-2866
Number of pages4
JournalOrvosi hetilap
Volume138
Issue number45
Publication statusPublished - Nov 9 1997

ASJC Scopus subject areas

  • Medicine(all)

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