Substrate-binder interfacial interactions were evaluated on the basis of the physico-chemical and mechanical properties of granules and compressed samples. Linear relationship was found between the breaking strength, the diffuse reflectance and the binder content of the examined granule-systems and compressed samples. The increasing amount of binder in the granules improved the adhesive interaction existing between the substrate and the binder. Our results indicate that the mechanical properties of the single particles as well as of the compressed samples were basically determined by the physico-chemical interactions of the substrate-binder interfacial layer. The qualitative and quantitative evaluation of these interactions has a decisive impact on the formulation and in process control of solid dosage forms of optimal mechanical properties.
|Translated title of the contribution||Evaluation of substrate-binder interfacial interactions|
|Number of pages||4|
|Journal||Acta pharmaceutica Hungarica|
|Publication status||Published - Mar 1 1998|
ASJC Scopus subject areas
- Pharmaceutical Science