Evaluation of substrate-binder interaction in a model granule system

F. Kiekens, R. Zelko, I. Antal, J. P. Remon

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The real binder function in granules made of PVP and glass ballotini as model substrates, and its effect on the mechanical properties of rectangular beam specimens consisting of these granules was investigated by use of the four-point beam-bending technique. The mechanical properties of the rectangular beam specimens were correlated with tile granulation liquid characteristics (contact angle, surface tension and binder concentration). The mechanical strength and Young's modulus of the specimens both reached a maximum value when the binder concentration in the granulation liquid was increased to 20% (w/v) for all granulation liquid volumes used. Above a 20% PVP concentration, the increasing granulation liquid contact angle hindered the binder spreading, creating weak regions in the compact and decreasing its mechanical strength. This was confirmed by scanning electron microscopy pictures showing a non-homogeneous distribution of the PVP in the granulated mass. No differences were observed in the stress/strain behaviour of the beams made with PVP of different molecular weight.

Original languageEnglish
Pages (from-to)175-182
Number of pages8
JournalInternational Journal of Pharmaceutics
Issue number2
Publication statusPublished - Jul 15 1998



  • Four-point beam bending
  • PVP
  • Substrate-binder interaction

ASJC Scopus subject areas

  • Pharmaceutical Science

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