Evaluation of serum-lipid-related cardiovascular risk factors in Alzheimer's disease

J. Kálmán, B. J. Kudchodkar, K. Murray, W. J. McConathy, A. Juhász, Z. Janka, Andras G. Lacko

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

There is now sufficient evidence to suggest that cardiovascular pathology and altered lipid metabolism contribute to the development of late-onset Alzheimer's disease (AD). In the present study, 24 AD patients and 15 controls were assessed for cardiovascular risk based on serum lipid and lipid oxidation parameters. The AD patients appeared to have a more favorable cardiovascular risk profile than the controls based on high-density lipoprotein cholesterol (HDL-C) values. The levels of thiobarbituric-acid-rective substances and the activity of the enzyme paraoxonase (PON) following copper oxidation indicate that female patients may have better protection against serum and perhaps tissue oxidants than males with AD. While the higher HDL-C values indicate lower cardiovascular risk, additional data on oxidized lipid parameters suggest a lower level of protection against serum oxidants in male AD probands.

Original languageEnglish
Pages (from-to)488-493
Number of pages6
JournalDementia and Geriatric Cognitive Disorders
Volume10
Issue number6
DOIs
Publication statusPublished - 1999

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Alzheimer Disease
Lipids
Serum
Oxidants
HDL Cholesterol
Aryldialkylphosphatase
Lipid Metabolism
Copper
Pathology
Enzymes

Keywords

  • Alzheimer's disease
  • Lipids
  • Lipoproteins
  • Oxidized lipids

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Geriatrics and Gerontology

Cite this

Evaluation of serum-lipid-related cardiovascular risk factors in Alzheimer's disease. / Kálmán, J.; Kudchodkar, B. J.; Murray, K.; McConathy, W. J.; Juhász, A.; Janka, Z.; Lacko, Andras G.

In: Dementia and Geriatric Cognitive Disorders, Vol. 10, No. 6, 1999, p. 488-493.

Research output: Contribution to journalArticle

Kálmán, J. ; Kudchodkar, B. J. ; Murray, K. ; McConathy, W. J. ; Juhász, A. ; Janka, Z. ; Lacko, Andras G. / Evaluation of serum-lipid-related cardiovascular risk factors in Alzheimer's disease. In: Dementia and Geriatric Cognitive Disorders. 1999 ; Vol. 10, No. 6. pp. 488-493.
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