Evaluation of oxidative stress markers in neonates with intra-uterine growth retardation

Zsuzsanna Hracsko, Hajnalka Orvos, Zoltan Novak, Attila Pal, Ilona S. Varga

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78 Citations (Scopus)

Abstract

Intra-uterine growth retardation (IUGR) is an abnormality of pregnancy. Neonates with IUGR weigh less than the 10th percentile for gestational age. The objective of the study was to identify the relationship between IUGR and the antioxidant status. Cord blood of 157 neonates with normal weight (control group) and 29 neonates with IUGR were included. The following parameters were determined and compared in the two groups: lipid peroxidation in the plasma, red blood cells and erythrocyte ghosts; protein and DNA damage; antioxidant enzyme activities (superoxide dismutase, catalase, glutathione, kroxidase); the level of reduced glutathione; and the ferric reducing ability of the plasma. The level of lipid peroxidation was significantly higher in the IUGR group. The antioxidant enzyme activities and the levels of antioxidants were significantly lower in the IUGR group. Damage of proteins and DNA was slightly, but non-significantly, higher in the lUGR group. Neonates with IUGR seem to have significant deficiencies in antioxidant defence. IUGR is correlated with significant oxidative stress.

Original languageEnglish
Pages (from-to)11-16
Number of pages6
JournalRedox Report
Volume13
Issue number1
DOIs
Publication statusPublished - Feb 1 2008

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Keywords

  • Antioxidant defence
  • Intra-uterine growth retardation
  • Neonates

ASJC Scopus subject areas

  • Biochemistry
  • Physiology
  • Clinical Biochemistry
  • Cell Biology
  • Biochemistry, medical

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