Evaluation of Objective Signs and Subjective Symptoms of Dry Eye Disease in Patients with Inflammatory Bowel Disease

Z. Barta, Levente Czompa, Aniko Rentka, Eva Zold, Judit Remenyik, Attila Biro, R. Gesztelyi, Judit Zsuga, Peter Szodoray, Adam Kemeny-Beke

Research output: Contribution to journalArticle

Abstract

Aim. To evaluate tear film parameters and relationship of objective clinical signs and subjective symptoms of dry eye disease (DED) in inflammatory bowel disease (IBD) subgroups. Methods. 39 patients with Crohn's disease (CD), 26 patients with ulcerative colitis (UC), and 39 control persons with no ocular symptoms or surface disorders were included in this prospective, case-control, and cross-sectional study. The ocular surface disease index (OSDI) questionnaire was applied to evaluate dry eye symptoms, and objective tests of DED were performed on both eyes of each subject. Results. The average of OSDI scores was 30.59 (±16.68) in CD patients, 24.67 (±23.48) in UC patients, and 11.19 (±5.8) in controls. Except for tear film breakup time (tBUT) and Schirmer-I values other objective parameters were better in UC patients, than in CD patients. CD patients rather than UC patients tend to develop DED. This was associated with immunosuppressant and TNF-α inhibitor use. Conclusions. Clinicians must be aware of the spectrum of DED involvement in IBD and suggest using artificial tears in order to decrease severity of ocular complications.

Original languageEnglish
Article number8310583
JournalBioMed Research International
Volume2019
DOIs
Publication statusPublished - Jan 1 2019

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Eye Diseases
Inflammatory Bowel Diseases
Signs and Symptoms
Ulcerative Colitis
Crohn Disease
Tears
Immunosuppressive Agents
Cross-Sectional Studies

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)

Cite this

Evaluation of Objective Signs and Subjective Symptoms of Dry Eye Disease in Patients with Inflammatory Bowel Disease. / Barta, Z.; Czompa, Levente; Rentka, Aniko; Zold, Eva; Remenyik, Judit; Biro, Attila; Gesztelyi, R.; Zsuga, Judit; Szodoray, Peter; Kemeny-Beke, Adam.

In: BioMed Research International, Vol. 2019, 8310583, 01.01.2019.

Research output: Contribution to journalArticle

Barta, Z. ; Czompa, Levente ; Rentka, Aniko ; Zold, Eva ; Remenyik, Judit ; Biro, Attila ; Gesztelyi, R. ; Zsuga, Judit ; Szodoray, Peter ; Kemeny-Beke, Adam. / Evaluation of Objective Signs and Subjective Symptoms of Dry Eye Disease in Patients with Inflammatory Bowel Disease. In: BioMed Research International. 2019 ; Vol. 2019.
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