Evaluation of mathematical models describing drug release from lipophilic matrices

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Abstract

Potassium chloride, as a highly watersoluble model drug was embedded into wax to produce sustained release dosage form. Samples were coated with different core:wall ratios to control the dissolution profile. The drug release from coated samples was tested by the rotating paddle method of USP and the dissolution data were analyzed assuming different kinetic models. Increasing the quantity of coating material may modify the drug liberation which was demonstrated by tile correlation between proportion of the embedding material and mean dissolution time. It can be concluded that changing the quantity of embedding material both the dissolution rate and kinetic profile can be controlled.

Original languageEnglish
Pages (from-to)61-64
Number of pages4
JournalInternational Journal of Pharmaceutics
Volume145
Issue number1-2
DOIs
Publication statusPublished - Dec 6 1996

Keywords

  • Dissolution kinetics
  • Highly watersoluble drug
  • Lipophilic matrix
  • Mathematical models
  • Statistical evaluation
  • Sustained drug release

ASJC Scopus subject areas

  • Pharmaceutical Science

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