Evaluation of lignans from Heliopsis helianthoides var. scabra for their potential antimetastatic effects in the brain

Zsanett Hajdu, János Haskó, I. Krizbai, I. Wilhelm, Nikoletta Jedlinszki, Csilla Fazakas, Judit Molnár, P. Forgó, J. Hohmann, Dezso Csupor

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Two new arylbenzofuran-type neolignans, 1″-dehydroegonol 3″-methyl ether (1) and egonol 3″-methyl ether (2), and four known lignan derivatives, namely, helioxanthin (3), (7E)-7,8-dehydroheliobuphthalmin (4), heliobuphthalmin (5), and 7-acetoxyhinokinin (6), were isolated from a chloroform-soluble partition of the methanol extract of the fresh roots of Heliopsis helianthoides var. scabra. These six compounds were evaluated in vitro in terms of their ability to inhibit the various steps involved in brain tumor metastasis formation. Compounds 3 and 4 inhibited the migration of both melanoma and brain endothelial cells, and 3 also reduced the adhesion of melanoma cells to the brain endothelium. Furthermore, 3 and 4 additionally enhanced the barrier function of the blood-brain barrier and the expression of the tight junction protein ZO-1 at the junctions of the endothelial cells. These findings suggest that 3 and 4 may have the potential to interfere with different steps of brain metastasis formation and to enhance the barrier function of cerebral endothelial cells.

Original languageEnglish
Pages (from-to)2641-2650
Number of pages10
JournalJournal of Natural Products
Volume77
Issue number12
DOIs
Publication statusPublished - Dec 26 2014

Fingerprint

Lignans
Brain
Endothelial cells
Endothelial Cells
Melanoma
Zonula Occludens-1 Protein
Neoplasm Metastasis
Chloroform
Blood-Brain Barrier
Cell Adhesion
Brain Neoplasms
Endothelium
Methanol
Tumors
Adhesion
Derivatives

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Analytical Chemistry
  • Organic Chemistry
  • Molecular Medicine
  • Complementary and alternative medicine
  • Medicine(all)

Cite this

Evaluation of lignans from Heliopsis helianthoides var. scabra for their potential antimetastatic effects in the brain. / Hajdu, Zsanett; Haskó, János; Krizbai, I.; Wilhelm, I.; Jedlinszki, Nikoletta; Fazakas, Csilla; Molnár, Judit; Forgó, P.; Hohmann, J.; Csupor, Dezso.

In: Journal of Natural Products, Vol. 77, No. 12, 26.12.2014, p. 2641-2650.

Research output: Contribution to journalArticle

Hajdu, Zsanett ; Haskó, János ; Krizbai, I. ; Wilhelm, I. ; Jedlinszki, Nikoletta ; Fazakas, Csilla ; Molnár, Judit ; Forgó, P. ; Hohmann, J. ; Csupor, Dezso. / Evaluation of lignans from Heliopsis helianthoides var. scabra for their potential antimetastatic effects in the brain. In: Journal of Natural Products. 2014 ; Vol. 77, No. 12. pp. 2641-2650.
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