Evaluation of ketamine systemic absorption from topical preparations: Short communication

G. Zapantis, Ildikó Csóka, E. Csányi, G. Horváth, I. Eros

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Abstract

The aim of this study was to evaluate the systemic absorption of the topically administered ketamine using different vehicles and additives, in order to develop a transdermal therapeutic system (TTS) of this drug. After the application of different ketamine preparations (1% in hydrogel, o/w cream, or organogel) the ketamine appeared in the blood. The lowest level could be observed with o/w cream, while the highest concentration was achieved by means of the hydrogel system, however this difference was not significant. Further studies are going to be performed with higher drug concentrations for the characterization of the differences in the pharmacodynamics of the drug with different vehicles and to evaluate the correlation between the in vitro and in vivo absorption.

Original languageEnglish
Pages (from-to)387-389
Number of pages3
JournalActa biologica Hungarica
Volume57
Issue number3
DOIs
Publication statusPublished - Oct 23 2006

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Keywords

  • Gel-cream
  • Ketamine
  • Topical
  • Transdermal drug delivery

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)
  • Neurology

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