Evaluation of iron status in European adolescents through biochemical iron indicators: The HELENA Study

M. Ferrari, L. Mistura, E. Patterson, M. Sjöström, L. E. Díaz, P. Stehle, M. Gonzalez-Gross, M. Kersting, K. Widhalm, D. Molnár, F. Gottrand, S. De Henauw, Y. Manios, A. Kafatos, L. A. Moreno, C. Leclercq

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Background/Objectives:To assess the iron status among European adolescents through selected biochemical parameters in a cross-sectional study performed in 10 European cities.Subjects/Methods:Iron status was defined utilising biochemical indicators. Iron depletion was defined as low serum ferritin (SF8.5 mg/l) plus iron depletion. Iron deficiency anaemia (IDA) was defined as ID with haemoglobin (Hb) below the WHO cutoff for age and sex: 12.0 g/dl for girls and for boys aged 12.5-14.99 years and 13.0 g/dl for boys aged ≥15 years. Enzyme linked immunosorbent assay was used as analytical method for SF, sTfR and C-reactive protein (CRP). Subjects with indication of inflammation (CRP >5 mg/l) were excluded from the analyses. A total of 940 adolescents aged 12.5-17.49 years (438 boys and 502 girls) were involved.Results:The percentage of iron depletion was 17.6%, significantly higher in girls (21.0%) compared with boys (13.8%). The overall percentage of ID and IDA was 4.7 and 1.3%, respectively, with no significant differences between boys and girls. A correlation was observed between log (SF) and Hb (r=0.36, P

Original languageEnglish
Pages (from-to)340-349
Number of pages10
JournalEuropean Journal of Clinical Nutrition
Volume65
Issue number3
DOIs
Publication statusPublished - Mar 2011

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Iron
Iron-Deficiency Anemias
C-Reactive Protein
Hemoglobins
Ferritins
Cross-Sectional Studies
Enzyme-Linked Immunosorbent Assay
Inflammation
Serum

Keywords

  • adolescent
  • anaemia
  • Europe
  • iron deficiency

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Ferrari, M., Mistura, L., Patterson, E., Sjöström, M., Díaz, L. E., Stehle, P., ... Leclercq, C. (2011). Evaluation of iron status in European adolescents through biochemical iron indicators: The HELENA Study. European Journal of Clinical Nutrition, 65(3), 340-349. https://doi.org/10.1038/ejcn.2010.279

Evaluation of iron status in European adolescents through biochemical iron indicators : The HELENA Study. / Ferrari, M.; Mistura, L.; Patterson, E.; Sjöström, M.; Díaz, L. E.; Stehle, P.; Gonzalez-Gross, M.; Kersting, M.; Widhalm, K.; Molnár, D.; Gottrand, F.; De Henauw, S.; Manios, Y.; Kafatos, A.; Moreno, L. A.; Leclercq, C.

In: European Journal of Clinical Nutrition, Vol. 65, No. 3, 03.2011, p. 340-349.

Research output: Contribution to journalArticle

Ferrari, M, Mistura, L, Patterson, E, Sjöström, M, Díaz, LE, Stehle, P, Gonzalez-Gross, M, Kersting, M, Widhalm, K, Molnár, D, Gottrand, F, De Henauw, S, Manios, Y, Kafatos, A, Moreno, LA & Leclercq, C 2011, 'Evaluation of iron status in European adolescents through biochemical iron indicators: The HELENA Study', European Journal of Clinical Nutrition, vol. 65, no. 3, pp. 340-349. https://doi.org/10.1038/ejcn.2010.279
Ferrari, M. ; Mistura, L. ; Patterson, E. ; Sjöström, M. ; Díaz, L. E. ; Stehle, P. ; Gonzalez-Gross, M. ; Kersting, M. ; Widhalm, K. ; Molnár, D. ; Gottrand, F. ; De Henauw, S. ; Manios, Y. ; Kafatos, A. ; Moreno, L. A. ; Leclercq, C. / Evaluation of iron status in European adolescents through biochemical iron indicators : The HELENA Study. In: European Journal of Clinical Nutrition. 2011 ; Vol. 65, No. 3. pp. 340-349.
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