Evaluation of intereye corneal asymmetry in patients with keratoconus. A Scheimpflug imaging study

Lóránt Dienes, Kinga Kránitz, Éva Juhász, Andrea Gyenes, A. Takács, Kata Miháltz, Zoltán Z. Nagy, I. Kovács

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Abstract

Methods: This study included 97 patients: 65 subjects with bilateral normal corneas (NC) and 32 with keratoconus (KC). Central corneal thickness (CCT), thinnest corneal thickness (ThCT) and posterior elevation (PE) at the thinnest point of the cornea were measured in both eyes using Scheimpflug imaging. Intereye asymmetry and its correlation with keratoconus severity were calculated for each variable. The area under the receiver operating characteristic curve (AUROC) was used to compare predictive accuracy of different variables for keratoconus.

Results: In normal eyes, intereye differences were significantly lower compared with the keratoconus eyes (p2 = 0.55, p2 = 0.39, p2 = 0.48, p2 = 0.64, p

Purpose: To assess the correlation between keratoconus severity and intereye asymmetry of pachymetric data and posterior elevation values and to evaluate their combined accuracy in discriminating normal corneas from those with keratoconus.

Conclusions: There is an increased intereye asymmetry in keratometry, pachymetry and posterior corneal elevation values in keratoconic patients compared to subjects with normal corneas. Keratoconus patients with more severe disease are also more asymmetric in their disease status which should be taken into account during clinical care.

Original languageEnglish
Article numbere108882
JournalPLoS One
Volume9
Issue number10
DOIs
Publication statusPublished - Oct 8 2014

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Keratoconus
cornea
image analysis
Imaging techniques
eyes
Cornea
Corneal Pachymetry
ROC Curve

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Evaluation of intereye corneal asymmetry in patients with keratoconus. A Scheimpflug imaging study. / Dienes, Lóránt; Kránitz, Kinga; Juhász, Éva; Gyenes, Andrea; Takács, A.; Miháltz, Kata; Nagy, Zoltán Z.; Kovács, I.

In: PLoS One, Vol. 9, No. 10, e108882, 08.10.2014.

Research output: Contribution to journalArticle

Dienes, Lóránt ; Kránitz, Kinga ; Juhász, Éva ; Gyenes, Andrea ; Takács, A. ; Miháltz, Kata ; Nagy, Zoltán Z. ; Kovács, I. / Evaluation of intereye corneal asymmetry in patients with keratoconus. A Scheimpflug imaging study. In: PLoS One. 2014 ; Vol. 9, No. 10.
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AU - Takács, A.

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AU - Nagy, Zoltán Z.

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