Evaluation of Histological and non-Invasive Methods for the Detection of Liver Fibrosis: The Values of Histological and Digital Morphometric Analysis, Liver Stiffness Measurement and APRI Score

Tünde Halász, Gábor Horváth, András Kiss, G. Pár, Andrea Szombati, Fanni Gelley, B. Nemes, I. Kenessey, Violetta Piurkó, Z. Schaff

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Prognosis and treatment of liver diseases mainly depend on the precise evaluation of the fibrosis. Comparisons were made between the results of Metavir fibrosis scores and digital morphometric analyses (DMA), liver stiffness (LS) values and aminotransferase-platelet ratio (APRI) scores, respectively. Liver biopsy specimens stained with Sirius red and analysed by morphometry, LS and APRI measurements were taken from 96 patients with chronic liver diseases (56 cases of viral hepatitis, 22 cases of autoimmune- and 18 of mixed origin). The strongest correlation was observed between Metavir score and DMA (r = 0.75 p <0.05), followed in decreasing order by LS and Metavir (r = 0.61), LS and DMA (r = 0.47) LS and APRI (r = 0.35) and Metavir and APRI (r = 0.24), respectively. DMA is a helpful additional tool for the histopathological evaluation of fibrosis, even when the sample size is small and especially in case of advanced fibrosis. The non-invasive methods showed good correlation with the histopathological methods; LS proved to be more accurate than APRI. The stronger correlation between LS values and Metavir scores, as well as the results of DMA in case of appropriate sample size were remarkable.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalPathology and Oncology Research
Volume22
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

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Transaminases
Liver Cirrhosis
Blood Platelets
Liver
Fibrosis
Sample Size
Liver Diseases
Hepatitis
Chronic Disease
Biopsy

Keywords

  • Digital morphometric analysis
  • Liver biopsy
  • Liver fibrosis
  • Liver stiffness

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Pathology and Forensic Medicine

Cite this

Evaluation of Histological and non-Invasive Methods for the Detection of Liver Fibrosis : The Values of Histological and Digital Morphometric Analysis, Liver Stiffness Measurement and APRI Score. / Halász, Tünde; Horváth, Gábor; Kiss, András; Pár, G.; Szombati, Andrea; Gelley, Fanni; Nemes, B.; Kenessey, I.; Piurkó, Violetta; Schaff, Z.

In: Pathology and Oncology Research, Vol. 22, No. 1, 01.01.2016, p. 1-6.

Research output: Contribution to journalArticle

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