Evaluation of hemostatic changes and blood antioxidant capacity in acute and chronic pancreatitis

L. Kerekes, P. Árkossy, I. Altorjay, M. Huszka, J. Kappelmayer, P. Tóth, Z. Szentkereszty, P. Sápy

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Background/Aims: We examined changes in hemostasis, in levels of total antioxidant capacity, and pancreatic enzymes (amylase, lipase) in patients with pancreatitis 1, 3 and 7 days after admission to the clinic, in order to evaluate the inflammatory processes in acute and chronic pancreatitis and to identify new prognostic markers. Methodology: The rate of CD62 expression -a marker of platelet hyperactivity- and the rate of platelet-leukocyte aggregates were measured by flow cytometry. The connection between the parameters measured and the severity of pancreatitis and also the differences of the parameters in acute and chronic pancreatitis were investigated. Results: On the basis of previous studies it was assumed, that there is a connection between the level of parameters measured and the inflammatory process in the pancreas, and also between the defending processes of the body against free radicals. Conclusions: Based on our results, we suggest to extend the laboratory measurements to the investigation of hemostatic parameters. The measurement of plasma level of fibrinogen, von Willebrand factor and the rate of platelet activation is especially important.

Original languageEnglish
Pages (from-to)1746-1749
Number of pages4
JournalHepato-Gastroenterology
Volume48
Issue number42
Publication statusPublished - 2001

Fingerprint

Chronic Pancreatitis
Hemostatics
Pancreatitis
Blood Platelets
Antioxidants
Platelet Activation
von Willebrand Factor
Amylases
Hemostasis
Lipase
Fibrinogen
Free Radicals
Pancreas
Flow Cytometry
Leukocytes
Enzymes

Keywords

  • Hemostatic changes
  • Pancreatitis
  • Platelet activation

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Evaluation of hemostatic changes and blood antioxidant capacity in acute and chronic pancreatitis. / Kerekes, L.; Árkossy, P.; Altorjay, I.; Huszka, M.; Kappelmayer, J.; Tóth, P.; Szentkereszty, Z.; Sápy, P.

In: Hepato-Gastroenterology, Vol. 48, No. 42, 2001, p. 1746-1749.

Research output: Contribution to journalArticle

Kerekes, L. ; Árkossy, P. ; Altorjay, I. ; Huszka, M. ; Kappelmayer, J. ; Tóth, P. ; Szentkereszty, Z. ; Sápy, P. / Evaluation of hemostatic changes and blood antioxidant capacity in acute and chronic pancreatitis. In: Hepato-Gastroenterology. 2001 ; Vol. 48, No. 42. pp. 1746-1749.
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AU - Altorjay, I.

AU - Huszka, M.

AU - Kappelmayer, J.

AU - Tóth, P.

AU - Szentkereszty, Z.

AU - Sápy, P.

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