Evaluation of gastric acid secretion at endoscopy with a modified Congo red test.

E. Tóth, Kristina Sjölund, Ola Thorsson, Henrik Thorlacius

Research output: Contribution to journalArticle

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Abstract

BACKGROUND: Markedly decreased or absent gastric acid production is associated with a number of clinically significant conditions, and identification of patients with hypo/achlorhydria may be important. However, current methods of assessing impaired acid secretion are unreliable, time-consuming, and/or complex. The aim of this prospective study was to evaluate a modified endoscopic Congo red test for the diagnosis of hypo/achlorhydria by correlation with a standard gastric acid secretory test. METHODS: One hundred six consecutive outpatients with or without dyspeptic symptoms referred for endoscopy were evaluated by using a modified endoscopic Congo red test and a standard test of gastric acid secretion. The modified endoscopic Congo red test suggested hypo/achlorhydria when there was no color shift or a shift of small extent (less than one third of fundic mucosa). Hypo/achlorhydria by the standard gastric acid secretory test was defined as a maximal acid output of less than 6.9 mmol/hour in men and 5.0 mmol/hour in women. RESULTS: The accuracy of the modified endoscopic Congo red test for the diagnosis of hypo/achlorhydria was 0.98 (95% CI [0.93, 0.99]). The sensitivity was 1.0 (95% CI [0.92, 1.00]) and specificity 0.96 (95% CI [0.88, 0.99]). All patients tolerated the modified endoscopic Congo red test well. CONCLUSION: The modified endoscopic Congo red is an accurate, simple, fast, inexpensive, and well-tolerated chromoendoscopic method for identification of patients with hypo/achlorhydria during routine upper endoscopy.

Original languageEnglish
Pages (from-to)254-259
Number of pages6
JournalGastrointestinal Endoscopy
Volume56
Issue number2
Publication statusPublished - Aug 2002

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Achlorhydria
Congo Red
Gastric Acid
Endoscopy
Acids
Mucous Membrane
Outpatients
Color
Prospective Studies

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Evaluation of gastric acid secretion at endoscopy with a modified Congo red test. / Tóth, E.; Sjölund, Kristina; Thorsson, Ola; Thorlacius, Henrik.

In: Gastrointestinal Endoscopy, Vol. 56, No. 2, 08.2002, p. 254-259.

Research output: Contribution to journalArticle

Tóth, E, Sjölund, K, Thorsson, O & Thorlacius, H 2002, 'Evaluation of gastric acid secretion at endoscopy with a modified Congo red test.', Gastrointestinal Endoscopy, vol. 56, no. 2, pp. 254-259.
Tóth, E. ; Sjölund, Kristina ; Thorsson, Ola ; Thorlacius, Henrik. / Evaluation of gastric acid secretion at endoscopy with a modified Congo red test. In: Gastrointestinal Endoscopy. 2002 ; Vol. 56, No. 2. pp. 254-259.
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