Evaluation of drug release from coated pellets based on isomalt, sugar, and microcrystalline cellulose inert cores

Nikolett Kállai, Oliver Luhn, Judit Dredán, Kristóf Kovács, Miléna Lengyel, István Antal

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The objective of the present study was to investigate the effect of the pellet core materials isomalt, sugar, and microcrystalline cellulose on the in vitro drug release kinetics of coated sustained-release pellets as well as to evaluate the influence of different ratios of polymethacrylate copolymers exhibiting different permeability characteristics on the drug release rate. For characterization of the drug release process of pellets, the effect of osmolality was studied using glucose as an osmotically active agent in the dissolution medium. The pellet cores were layered with diclofenac sodium as model drug and coated with different ratios of Eudragit® RS30D and Eudragit® RL30D (ERS and ERL; 0:1 and 0.5:0.5 and 1:0 ratio) in a fluid bed apparatus. Physical characteristics such as mechanical strength, shape, and size proved that the inert cores were adequate for further processing. The in vitro dissolution tests were performed using a USP Apparatus I (basket method). The results demonstrated that, besides the ratio of the coating polymers (ERS/ERL), the release mechanism was also influenced by the type of starter core used. Sugar- and isomalt-type pellet cores demonstrated similar drug release profiles.

Original languageEnglish
Pages (from-to)383-391
Number of pages9
JournalAAPS PharmSciTech
Volume11
Issue number1
DOIs
Publication statusPublished - Mar 2010

Keywords

  • Diclofenac sodium dissolution
  • Inert pellet core
  • Isomalt
  • Microcrystalline cellulose
  • Sugar

ASJC Scopus subject areas

  • Pharmaceutical Science

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