Hatóanyagfelszabadulás értékelése különbözo matematikai módszerekkel új "soft-patch" típusú gélrendszerekbol

Translated title of the contribution: Evaluation of drug liberation from "soft-patch" type gel systems by different mathematical models

Gabriella Csóka, Sylvia Marton, I. Rácz

Research output: Contribution to journalArticle

Abstract

Authors investigate "soft-patch" type transdermal delivery gel systems with NSAID (diclofenac-Na). The matrix systems containing 1% pharmacon in dissolved (stearate gel) and in suspended form (PEG and lipophilic gel). The in vitro dissolution test was performed according to USP TTS directives. The acidic skin wrap was simulated by buffer solution of pH=5.5, the liberated and dissolved fraction of drug was determined spectrophotometrically. The rate constants were calculated using different mathematical models (first order kinetics, Fick's law, Higuchi equation, modified Nernst equation /Rácz et al./, Hixon relationship). The aim of investigations was to determine the fit of equations to measurement results, namely in which situation is the rate constant independent of time. The comparison was based on RSD and R2 values. The modified Nernst equation (Rácz's relationship) passed the best on data in the case of all three gel systems, the calculated values were constant at any time point. The shape parameter value (a) confirmed the alterations in liberation processes. The less correlation was observed in the case of Hixon-Crowel equation.

Original languageHungarian
Pages (from-to)102-106
Number of pages5
JournalActa Pharmaceutica Hungarica
Volume74
Issue number2
Publication statusPublished - 2004

Fingerprint

Theoretical Models
Gels
Transdermal Patch
Stearates
Diclofenac
Non-Steroidal Anti-Inflammatory Agents
Buffers
Skin
Drug Liberation
Pharmaceutical Preparations

ASJC Scopus subject areas

  • Pharmaceutical Science

Cite this

Hatóanyagfelszabadulás értékelése különbözo matematikai módszerekkel új "soft-patch" típusú gélrendszerekbol. / Csóka, Gabriella; Marton, Sylvia; Rácz, I.

In: Acta Pharmaceutica Hungarica, Vol. 74, No. 2, 2004, p. 102-106.

Research output: Contribution to journalArticle

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