Diabeteses kisér-károsodás vizsgálata optikai koherencia tomográfián alapuló angiográfiával

Translated title of the contribution: Evaluation of diabetic microangiopathy using optical coherence tomography angiography

Czakó Cecília, Sándor Gábor László, Ecsedy Mónika, Szepessy Zsuzsanna, Borbándy Ágnes, Resch Miklós, Papp András, Récsán Zsuzsa, Horváth Hajnalka, Nagy Zoltán Zsolt, I. Kovács

Research output: Contribution to journalArticle

Abstract

Introduction: Optical coherence tomography angiography is a non-invasive imaging technique that is able to visualize the different retinal vascular layers using motion contrast to detect blood flow without intravenous dye injection. This method might help to assess microangiopathy in diabetic retinopathy during screening and follow-up. Aim: To quantify retinal microvasculature alterations in both eyes of diabetic patients in relation to systemic risk factors using optical coherence tomography angiography. Method: Both eyes of 36 diabetic patients and 45 individuals without diabetes were examined. Duration of diabetes, insulin therapy, blood pressure, HbA1c, dyslipidemia, axial length and the presence of diabetic retinopathy were recorded. Retinal vessel density was measured by optical coherence tomography angiography. The effect of risk factors on vessel density and between-eye asymmetry was assessed using multivariable regression analysis. Results: Vessel density was significantly lower and between-eye difference was significantly higher in diabetic patients compared to controls (p<0.05). Both vessel density and between-eye asymmetry significantly correlated with diabetes duration (p<0.05) after controlling for the effect of risk factors. The between-eye asymmetry in vessel density was significantly higher in patients without clinically detectable diabetic retinopathy compared to control subjectsConclusions: There is a decrease in retinal vessel density and an increase in between-eye asymmetry in patients with diabetes compared to healthy subjects. By using optical coherence tomography angiography, the detection of these microvascular alterations is possible before clinically detectable diabetic retinopathy and might serve as a useful tool in both screening and timing of treatment.

Original languageHungarian
Pages (from-to)320-326
Number of pages7
JournalOrvosi Hetilap
Volume159
Issue number8
DOIs
Publication statusPublished - Feb 1 2018

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ASJC Scopus subject areas

  • Medicine(all)

Cite this

Cecília, C., László, S. G., Mónika, E., Zsuzsanna, S., Ágnes, B., Miklós, R., András, P., Zsuzsa, R., Hajnalka, H., Zsolt, N. Z., & Kovács, I. (2018). Diabeteses kisér-károsodás vizsgálata optikai koherencia tomográfián alapuló angiográfiával. Orvosi Hetilap, 159(8), 320-326. https://doi.org/10.1556/650.2018.30962