Evaluation of compression behavior of paracetamol tablets produced with β-cyclodextrin dispersions. Part II: Energy distribution study of tablets

Lj Tasić, K. Pintye-Hódi, P. Sabo-Revesz

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

The compression behavior of three paracetamol/β-cyclodextrin solid dispersions (PAR/β-CD, ratio 1:1 w/w, which differ in particle size, shape, and crystallinity, were studied using force-displacement measurements (F-D plots). The measured parameters included: effective work, expansion work, friction work, useful work, and plasticity derived from F-D plots at the tableting stage. The PAR/β-CD spray-dried solid dispersion has the best compressional behavior, compared to other dispersions (PAR/β-CD physical mixture and PAR/β-CD kneaded solid dispersion) and PAR alone. Energy distribution study also showed that β-CD has positive influence on the PAR compression characteristics.

Original languageEnglish
Pages (from-to)1153-1158
Number of pages6
JournalDrug development and industrial pharmacy
Volume23
Issue number12
DOIs
Publication statusPublished - Jan 1 1997

ASJC Scopus subject areas

  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry

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