Evaluation of clinical and laboratory features of antiphospholipid syndrome

A retrospective study of 637 patients

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54 Citations (Scopus)

Abstract

We retrospectively analysed the data of 1519 antiphospholipid antibody (APLA) positive patients between 1986 and 1999. Among them 637 were considered to have antiphospholipid syndrome (APS) based on the 1999 preliminary classification criteria, while 704 patients had no clinical signs of the syndrome. Our aim was to compare the autoantibody profile and clinical characteristics of primary and secondary APS, moreover to evaluate the associations between different APLA and specific symptoms attributable to APS. In our results, the APLA profiles for primary and SLE-associated secondary APS were similar. Among the evaluated clinical symptoms, cerebrovascular thrombosis was found to be more frequent in the SLE-associated, than in the primary APS group (P=0.04). We identified important differences in the clinical profile of patient populations with various types of APLA. Venous thrombosis occurred more frequently in subjects with lupus anticoagulant (LA), than in those with IgG or IgM type ACLA (P

Original languageEnglish
Pages (from-to)302-307
Number of pages6
JournalLupus
Volume12
Issue number4
DOIs
Publication statusPublished - 2003

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Antiphospholipid Syndrome
Antiphospholipid Antibodies
Retrospective Studies
Lupus Coagulation Inhibitor
Venous Thrombosis
Autoantibodies
Immunoglobulin M
Thrombosis
Immunoglobulin G
Population

Keywords

  • Anticardiolipin antibodies
  • Consensus criteria
  • Lupus anticoagulant
  • Primary APS
  • Secondary APS

ASJC Scopus subject areas

  • Rheumatology
  • Immunology

Cite this

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abstract = "We retrospectively analysed the data of 1519 antiphospholipid antibody (APLA) positive patients between 1986 and 1999. Among them 637 were considered to have antiphospholipid syndrome (APS) based on the 1999 preliminary classification criteria, while 704 patients had no clinical signs of the syndrome. Our aim was to compare the autoantibody profile and clinical characteristics of primary and secondary APS, moreover to evaluate the associations between different APLA and specific symptoms attributable to APS. In our results, the APLA profiles for primary and SLE-associated secondary APS were similar. Among the evaluated clinical symptoms, cerebrovascular thrombosis was found to be more frequent in the SLE-associated, than in the primary APS group (P=0.04). We identified important differences in the clinical profile of patient populations with various types of APLA. Venous thrombosis occurred more frequently in subjects with lupus anticoagulant (LA), than in those with IgG or IgM type ACLA (P",
keywords = "Anticardiolipin antibodies, Consensus criteria, Lupus anticoagulant, Primary APS, Secondary APS",
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AU - Soltész, P.

AU - Veres, K.

AU - Lakos, G.

AU - Kiss, E.

AU - Muszbek, L.

AU - Szegedi, G.

PY - 2003

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N2 - We retrospectively analysed the data of 1519 antiphospholipid antibody (APLA) positive patients between 1986 and 1999. Among them 637 were considered to have antiphospholipid syndrome (APS) based on the 1999 preliminary classification criteria, while 704 patients had no clinical signs of the syndrome. Our aim was to compare the autoantibody profile and clinical characteristics of primary and secondary APS, moreover to evaluate the associations between different APLA and specific symptoms attributable to APS. In our results, the APLA profiles for primary and SLE-associated secondary APS were similar. Among the evaluated clinical symptoms, cerebrovascular thrombosis was found to be more frequent in the SLE-associated, than in the primary APS group (P=0.04). We identified important differences in the clinical profile of patient populations with various types of APLA. Venous thrombosis occurred more frequently in subjects with lupus anticoagulant (LA), than in those with IgG or IgM type ACLA (P

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