Evaluation of anticonvulsant drugs during pregnancy in a population-based Hungarian study

A. E. Czeizel, M. Bod, P. Halász

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Abstract

The Hungarian Case-Control Surveillance of Congenital Anomalies, from 1980–1987, involved 10,698 malformed cases and 21,546 non-malformed controls. Ninety-five pregnant women were treated by 144 anticonvulsants excluding diazepam and barbiturates. The rate of anticonvulsant use was 2.9 times higher in pregnant women having malformed offspring than in control mothers and this difference was greater in polytherapy than in monotherapy.

Original languageEnglish
Pages (from-to)122-127
Number of pages6
JournalEuropean Journal of Epidemiology
Volume8
Issue number1
DOIs
Publication statusPublished - Jan 1992

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Keywords

  • Anticonvulsant drug intake
  • Congenital anomalies
  • Pregnancy

ASJC Scopus subject areas

  • Epidemiology

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